Transition-metal-free synthesis of phenanthridinones from biaryl-2-oxamic acid under radical conditions.
Transition-metal-free synthesis of phenanthridinones from biaryl-2-oxamic acid under radical conditions.
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DOI：
10.1021/ol503459s
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发表时间：
2015-01
期刊：
影响因子：
5.2
通讯作者：
Ming Yuan;Li Chen;Junwei Wang;Shenjie Chen;Kongchao Wang;Yongbo Xue;Guangmin Yao;Zeng-wei Luo;Yonghui Zhang
中科院分区：
文献类型：
--
作者：
Ming Yuan;Li Chen;Junwei Wang;Shenjie Chen;Kongchao Wang;Yongbo Xue;Guangmin Yao;Zeng-wei Luo;Yonghui Zhang
研究了以na2s2o8为助剂的双芳基-2-肟酸脱羧环化非苯噻酮。这项工作说明了在无过渡金属条件下非活化芳烃的分子内脱羧酰胺化的第一个例子。此外，这种方法提供了一种高效和经济的方法来获得生物学上有趣的菲苯二酮，这是许多天然产物中的重要结构基序。
Na2S2O8-promoted decarboxylative cyclization of biaryl-2-oxamic acid for phenanthridinones has been developed. This work illustrates the first example of intramolecular decarboxylative amidation of unactivated arene under transition-metal-free conditions. Additionally, this approach provides an efficient and economical method to access biologically interesting phenanthridinones, an important structure motif in many natural products.