DENDRODENDRITIC SYNAPTIC PATHWAY FOR INHIBITION IN OLFACTORY BULB
DENDRODENDRITIC SYNAPTIC PATHWAY FOR INHIBITION IN OLFACTORY BULB
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DOI：
10.1016/0014-4886(66)90023-9
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发表时间：
1966-01-01
影响因子：
5.3
通讯作者：
BRIGHTMAN, MW
中科院分区：
文献类型：
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作者：
RALL, W;SHEPHERD, GM;BRIGHTMAN, MW
基于对哺乳动物嗅球的独立研究的解剖学和生理学证据指向树突之间的突触相互作用。通过对兔嗅球电势的理论分析，初步得出二尖瓣树突突触刺激颗粒树突，颗粒树突突触抑制二尖瓣树突的结论。在一个独立的电子显微研究大鼠嗅球，突触收缩发现颗粒和二尖瓣树突之间。一个不寻常的特征是在二尖瓣树突末端的单个颗粒上出现多个突触接触；从这些突触接触的形态学推断，相对于相邻的二尖瓣树突，单个颗粒末端通常在一个点是突触前的，在相邻的点是突触后的。我们假设这些突触接触介导二尖瓣到颗粒的兴奋和颗粒到二尖瓣的抑制。这些树突突触可能提供了侧抑制和自我抑制的途径。
Anatomical and physiological evidence based on independent studies of the mammalian olfactory bulb points to synaptic interactions between dendrites. A theoretical analysis of electric potentials in the rabbit olfactory bulb led originally to the conclusion that mitral dendrites synaptically excite granule dendrites and granule dendrites then synaptically inhibit mitral dendrites. In an independent electron micrographic study of the rat olfactory bulb, synaptic contracts were found between granule and mitral dendrites. An unusual feature was the occurrence of more than one synaptic contact per single granule ending on a mitral dendrite; as inferred from the morphology of these synaptic contacts, a single granule ending was often presynaptic at one point and postsynaptic at an adjacent point with respect to the contiguous mitral dendrite. We postulate that these synaptic contacts mediate mitral-to-granule excitation and granule-to-mitral inhibition. These dendrodendritic synapses could provide a pathway for both lateral and self inhibition.