MEG Oscillatory Slowing in Cognitive Impairment is Associated with the Presence of Subjective Cognitive Decline
MEG Oscillatory Slowing in Cognitive Impairment is Associated with the Presence of Subjective Cognitive Decline
复制标题
DOI：
10.1177/15500594221072708
复制
发表时间：
2022-02-21
影响因子：
2
通讯作者：
Becker, James T.
中科院分区：
文献类型：
--
作者：
Bruna, Ricardo;Lopez-Sanz, David;Becker, James T.
阿尔茨海默病背后的机制尚未完全描述，患者在整个疾病过程中的电生理学变化可能有助于了解他们。在这项工作中，我们研究了一组129人的功率谱分布，这些人来自布莱恩老龄化和痴呆症连接学项目。从这个样本中，我们闭着眼睛获取了无任务数据，并估计了源空间中的功率谱分布。我们比较了三组人的频谱特征：70名健康对照，27名遗忘型MCI患者，32名无主观主诉(IWOC)的认知障碍患者。结果显示，与健康对照组和IWOC个体相比，aMCI患者的大脑活动放缓。这些差异既表现为高频振荡功率的降低，也表现为阿尔法振荡功率的增加。频谱减慢主要集中在顶叶和额叶内侧。我们能够验证患有aMCI的个体的大脑活动放缓，出现在我们的样本中与默认模式网络相关的区域。然而，这种模式在IWOC患者中没有出现，这表明他们的情况不是AD连续体的一部分。这项工作提出了关于这群人的有趣问题，以及他们认知障碍背后的潜在大脑机制。
The mechanisms behind Alzheimer's disease are not yet fully described, and changes in the electrophysiology of patients across the continuum of the disease could help to understand them. In this work, we study the power spectral distribution of a set of 129 individuals from the Connectomics of Brian Aging and Dementia project. From this sample, we acquired task-free data, with eyes closed, and estimated the power spectral distribution in source space. We compared the spectral profiles of three groups of individuals: 70 healthy controls, 27 patients with amnestic MCI, and 32 individuals showing cognitive impairment without subjective complaints (IWOC). The results showed a slowing of the brain activity in the aMCI patients, when compared to both the healthy controls and the IWOC individuals. These differences appeared both as a decrease in power for high frequency oscillations and an increase in power in alpha oscillations. The slowing of the spectrum was significant mainly in parietal and medial frontal areas. We were able to validate the slowing of the brain activity in individuals with aMCI, appearing in our sample in areas related to the default mode network. However, this pattern did not appear in the IWOC individuals, suggesting that their condition is not part of the AD continuum. This work raises interesting questions about this group of individuals, and the underlying brain mechanisms behind their cognitive impairment.