GENETIC INFLUENCES ON AGE-RELATED CHANGE IN TOTAL CHOLESTEROL, LOW-DENSITY LIPOPROTEIN-CHOLESTEROL, AND TRIGLYCERIDE LEVELS - LONGITUDINAL APOLIPOPROTEIN-E GENOTYPE EFFECTS
GENETIC INFLUENCES ON AGE-RELATED CHANGE IN TOTAL CHOLESTEROL, LOW-DENSITY LIPOPROTEIN-CHOLESTEROL, AND TRIGLYCERIDE LEVELS - LONGITUDINAL APOLIPOPROTEIN-E GENOTYPE EFFECTS
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DOI：
10.1002/gepi.1370110407
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发表时间：
1994-01-01
影响因子：
2.1
通讯作者：
DEEB, S
中科院分区：
文献类型：
--
作者：
JARVIK, GP;AUSTIN, MA;DEEB, S
本研究旨在探讨载脂蛋白E（ape E）基因型对老年男性总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）水平年龄相关变化的可能影响。载脂蛋白E是LDL的一种成分，是LDL受体的配体，载脂蛋白E基因型与TC和LDL-C平均水平的变化一致相关，并且似乎也影响TG水平。使用平均年龄为48 - 63岁的男性双胞胎，比较了具有133 - 134基因型和133 - 134基因型个体的TC、LDL-C和TG随时间的变化。在第1次检查时，2013年3月3日组的平均TC和LDL-C水平低于2013年4月4日组，但在第3次检查时，2013年3月3日组的平均TC和LDL-C水平显著高于2013年4月4日组。TC和LDL-C随年龄的变化率在2003 - 2003和2003 - 2004组之间差异显著。TG结果无统计学显著性。这些结果表明，载脂蛋白E基因型对冠心病风险的影响可能是年龄依赖性的。这项研究证明了纵向研究在完善疾病遗传风险因素模型方面的价值。(C)1994 Wiley-Liss，Inc.
This study addressed the possible influence of apolipoprotein E (ape E) genotype on age-related changes in total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and triglyceride (TG) levels in older males. Apo E is a component of LDL, is a ligand for the LDL receptor, and apo E genotype has been consistently associated with variation in mean levels of TC and LDL-C, and also appears to influence TG levels. Using male twins followed longitudinally between mean ages of 48 and 63 years, the change in TC, LDL-C, and TG over time for individuals with the epsilon 3 epsilon 3 and the epsilon 3 epsilon 4 genotypes was contrasted. At exam 1 mean TC and LDL-C levels were lower in the epsilon 3 epsilon 3 group than in the epsilon 3 epsilon 4 group, but at exam 3 mean TC and LDL-C levels were significantly higher in the epsilon 3 epsilon 3 group than in the epsilon 3 epsilon 4 group. The rate of change in TC and LDL-C with age differed significantly between epsilon 3 epsilon 3 and epsilon 3 epsilon 4 groups. Results for TG were not statistically significantly. These findings suggest that the apo E genotype effects on risk of coronary artery disease may be age-dependent. This study demonstrates the value of longitudinal studies in refining models for genetic risk factors for disease. (C) 1994 Wiley-Liss, Inc.