Conservation of hippocampal memory function in rats and humans
Conservation of hippocampal memory function in rats and humans
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DOI：
10.1038/379255a0
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发表时间：
1996-01-18
期刊：
影响因子：
64.8
通讯作者：
Eichenbaum, H
中科院分区：
文献类型：
--
作者：
Bunsey, M;Eichenbaum, H
海马体对于人类的陈述性记忆至关重要(1)。这种记忆涉及可以灵活访问的项目或事件之间的关联，以指导各种甚至新情况下的记忆表达（2-4）。在动物中，关于海马体是否专门负责空间记忆 (5,6) 还是它是否像人类那样介导一般记忆功能 (3,4)，一直存在争议。为了解决这个问题，我们训练了正常大鼠和海马损伤的大鼠进行非空间刺激-刺激关联，然后探究它们记忆表征的本质。我们在这里报告，正常大鼠表现出两种形式的灵活记忆表达：及物性，对共享共同元素的刺激对进行推理判断的能力，以及对称性，将与训练顺序相反的成对元素关联起来的能力。仅限于海马体的神经毒性损伤的大鼠没有表现出两种形式的灵活表达，表明非空间陈述性处理特别依赖于动物的海马体，就像人类一样。
THE hippocampus is critical to declarative memory in humans(1). This kind of memory involves associations among items or events that can be accessed flexibly to guide memory expression in various and even new situations(2-4). In animals, there has been controversy about whether the hippocampus is specialized for spatial memory(5,6) or whether it mediates a general memory function(3,4), as it does in humans. To address this issue we trained normal rats and rats with hippocampal damage on non-spatial stimulus-stimulus associations, then probed the nature of their memory representations. We report here that normal rats demonstrated two forms of flexible memory expression, transitivity, the ability to judge inferentially across stimulus pairs that share a common element, and symmetry, the ability to associate paired elements presented in the reverse of training order. Rats with neurotoxic damage limited to the hippocampus demonstrated neither form of flexible expression, indicating that non-spatial declarative processing depends specifically on the hippocampus in animals as it does in humans.,