One-pot synthesis of tetrasubstituted 2-aminofurans via Au-catalyzed cascade reaction of ynamides with propargylic alcohols
One-pot synthesis of tetrasubstituted 2-aminofurans via Au-catalyzed cascade reaction of ynamides with propargylic alcohols
复制标题
Au催化炔酰胺与炔丙醇级联反应一锅法合成四取代2-氨基呋喃
DOI：
10.1039/d1ob01910d
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Sato Yoshihiro
中科院分区：
文献类型：
--
作者：
Miyairi Asaki;Oonishi Yoshihiro;Sato Yoshihiro
采用金(I)催化酰胺与丙炔醇级联反应，实现了一锅法合成完全取代的2-氨基呋喃。氨基酰胺与丙炔醇的氢烷氧基化、Saucy-Marbet重排和合成的3,4-二氨基酰胺的环化依次在非常温和的条件下进行一锅反应，得到完全取代的2-氨基呋喃。
One-pot synthesis of fully substituted 2-aminofurans via a Au(I)-catalyzed cascade reaction of ynamides and propargylic alcohol was realized. Hydroalkoxylation of ynamide with propargylic alcohol, Saucy–Marbet rearrangement, and cyclization of the resultant 3,4-dienamide sequentially proceeds in a one-pot reaction under highly mild conditions to give fully substituted 2-aminofurans.