Neuroendocrine Tumor Epidemiology Contrasting Norway and North America
Neuroendocrine Tumor Epidemiology Contrasting Norway and North America
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DOI：
10.1002/cncr.23883
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发表时间：
2008-11-15
期刊：
影响因子：
6.2
通讯作者：
Modlin, Irvin M.
中科院分区：
文献类型：
--
作者：
Hauso, Oyvind;Gustafson, Bjorn I.;Modlin, Irvin M.
背景美国国家癌症研究所的监测、流行病学和最终结果（SEER）计划已被证明是美国神经内分泌肿瘤（NET）流行病学的重要资源。挪威还拥有一个强大而详细的癌症登记处：挪威癌症登记处（NRC）。将SEER NET数据与1993年至2004年期间相应的NRC数据进行比较，以确定挪威和美国之间NET流行病学是否存在差异。SEER和NRC分别报告了17，312和2030名NET。总体白人SEER NET发生率为4.44，而NRC为3.24。在SEER白色亚组中，支气管肺炎NET最常见（发生率= 1.42;占所有NET的32%），而在NRC中小肠NET最常见（0.81; 26%）。与1993年至1997年相比，2000年至2004年期间观察到SEER NET发生率显著增加（37%-40%）; NRC的增加更为明显（72%）。非裔美国人表现出非常高的总NET发生率为6.50;此外，在非裔美国人中，直肠NETS最常见（1.65; 27%）。在所有人群中，男性小肠NET发生率比女性高出30%。两个数据库中直肠NET的5年生存率最高（74%-88%），而前列腺NET的结局最差（0%-23%）。在诊断时，NETs局限于27%至46%的患者。美国高加索人群和挪威的NET发病率相似，但非洲裔美国人的NET发病率要高得多（接近50%）。NET被认为是惰性肿瘤;然而，5年生存率仅为55%。Cancer 2008; 113：2655-64. (C)2008美国癌症协会
BACKGROUND. The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program has proven to be a significant resource in US neuroendocrine tumor (NET) epidemiology. Norway also holds a robust and detailed cancer registry: the Norwegian Registry of Cancer (NRC).METHODS. SEER NET data were compared with corresponding NRC data in the time period 1993 to 2004 to determine whether there are differences in NET epidemiology between Norway and the United States.RESULTS. The SEER and NRC reported 17,312 and 2030 NETs, respectively. The overall Caucasian SEER NET incidence was 4.44, compared with 3.24 in the NRC. In the SEER white subset, bronchopulmonary NETs were the most common (incidence = 1.42; 32% of all NETs), compared with small intestinal NETs in the NRC (0.81; 26%). A marked increase in SEER NET incidence (37%-40%) was observed in the period 2000 to 2004, compared with 1993 to 1997; an even more pronounced increase (72%) was seen in the NRC. African Americans exhibited a remarkably high overall NET incidence of 6.50; furthermore, among African Americans, rectal NETS were most common (1.65; 27%). Small intestinal NET incidence was similar to 30% higher in men compared with women in all populations. The highest 5-year survival rates were for rectal NETs (74%-88%) in both databases, whereas prostatic NETs had the worst outcome (0%-23%). At diagnosis, NETs were localized in 27% to 46% of patients.CONCLUSIONS. NET incidence in the US Caucasian population and in Norway is similar, but considerably higher (similar to 50%) among African Americans. NETs have been regarded as indolent tumors; however, the 5-year survival is only similar to 55%. Cancer 2008; 113:2655-64. (C) 2008 American Cancer Society.