Relationship Between Obesity and Obesity-Related Morbidities Weakens With Aging
Relationship Between Obesity and Obesity-Related Morbidities Weakens With Aging
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DOI：
10.1093/gerona/glt026
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发表时间：
2014-01-01
影响因子：
5.1
通讯作者：
Kuk, Jennifer L.
中科院分区：
文献类型：
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作者：
Canning, Karissa L.;Brown, Ruth E.;Kuk, Jennifer L.
背景在老年人群中，肥胖与死亡风险之间存在微弱的关系，然而，年龄对肥胖与发病率之间关系的影响尚不清楚。本研究的目的是确定年龄对肥胖与心血管疾病、2型糖尿病、血脂异常和高血压之间关系的影响。数据来自第三次全国健康与营养调查（1988-1994）。个体被分为特定年龄（年轻：18-40岁;中年：40-65岁;老年：65-75岁;非常老年：>= 75岁）和体重指数（BMI; 18.5-24.9，>25-29.9，>= 30 kg/m2）类别。通过测量代谢危险因素、医生诊断或药物使用对心血管疾病、2型糖尿病、血脂异常和高血压进行分类。年龄改变了BMI与心血管疾病（年龄x BMI交互作用，p = 0.049）、血脂异常（年龄x BMI交互作用，男性p = 0.035，女性p <0.001）和女性高血压（年龄x BMI交互作用，p = 0.023）之间的关系，但男性没有（p = 0.167）。然而，年龄并没有改变BMI和2型糖尿病之间的关系（年龄x BMI相互作用，p = 0.177）。BMI与中青年人群心血管疾病、血脂异常、2型糖尿病和高血压的相对危险性增加密切相关，但随着年龄的增长，BMI与这些代谢疾病的相关性逐渐减弱。肥胖与普遍代谢状况之间的关联在年轻和中年人群中比在老年和非常老年的人群中更强。需要进行纵向研究来验证这些发现，并确认减肥对整个生命周期的健康益处。
Background. A weak relationship exists between obesity and mortality risk in older populations, however, the influence of age on the relationship between obesity and morbidity is unclear. The objective of this study was to determine the influence of age on the relationship between obesity and cardiovascular disease, type 2 diabetes, dyslipidemia, and hypertension.Methods. Data from the Third National Health and Nutrition Examination Survey (1988-1994) were used. Individuals were classified into specific age (young: 18-40; middle: 40-65; old: 65-75; and very old: >= 75 years) and body mass index (BMI; 18.5-24.9, >25-29.9, >= 30 kg/m(2)) categories. Cardiovascular disease, type 2 diabetes, dyslipidemia, and hypertension were categorized using measured metabolic risk factors, physician diagnosis, or medication use.Results. Age modified the relationship between BMI and cardiovascular disease (Age x BMI interaction, p = .049), dyslipidemia (Age x BMI interaction, p = .035 for men, p < .001 for women), and hypertension (Age x BMI interaction, p = .023) in women but not in men (p = .167). However, age did not modify the relationship between BMI and type 2 diabetes (Age x BMI interaction, p = .177). BMI was strongly associated with increased relative risk of cardiovascular disease, dyslipidemia, type 2 diabetes, and hypertension in the young and middle aged, however, the association between BMI and these metabolic conditions were much more attenuated with increasing age.Conclusion. A stronger association between obesity and prevalent metabolic conditions exists in young and middle-aged populations than in old and very old populations. Longitudinal studies are needed to verify these findings and to confirm the benefits of weight loss on health across the life span.