A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP.
A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP.
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DOI：
10.5607/en.2012.21.4.136
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发表时间：
2012-12
影响因子：
2.4
通讯作者：
Kida S
中科院分区：
文献类型：
--
作者：
Kida S
cAMP反应元件结合蛋白（CREB），一种转录因子，已被证明在记忆形成中发挥核心作用，其在这一过程中的参与已被研究使用了广泛的动物模型，从线虫到高等动物。已经开发和研究了各种CREB突变小鼠。CREB功能缺失的几种类型的突变小鼠具有受损的记忆形成和长时程增强（LTP），这表明CREB在这些过程中起着重要作用。为了进一步表征CREB在记忆形成和LTP中的作用，已经产生并分析了显示CREB功能获得的突变小鼠。重要的是，CREB-DIEDML小鼠和CREB-Y134 F小鼠表现出增强的记忆形成，而CREB-VP 16小鼠表现出降低的长期LTP（L-LTP）诱导阈值，这强烈表明CREB作为记忆形成和LTP的正调节剂发挥作用。本文就CREB基因激活在LTP和记忆形成中的作用进行综述。
cAMP response element-binding protein (CREB), a transcription factor, has been shown to play a central role in memory formation, and its involvement in this process has been investigated using a wide range of animal models, from nematodes to higher animals. Various CREB mutant mice have been developed and investigated. Several types of mutant mice with loss of CREB function have impaired memory formation and long-term potentiation (LTP), suggesting that CREB plays essential roles in these processes. To characterize the roles of CREB in memory formation and LTP further, mutant mice displaying gain of CREB function have been generated and analyzed. Importantly, CREB-DIEDML mice and CREB-Y134F mice showed enhanced memory formation, whereas CREB-VP16 mice displayed a lowered threshold of long-lasting LTP (L-LTP) induction, strongly suggesting that CREB functions as a positive regulator of memory formation and LTP. In this review, I focus on the effects of the genetic activation of CREB in LTP and memory formation and summarize previous findings.