Successful treatment of unresectable recurrent cutaneous squamous cell carcinoma of the scalp with meningeal invasion with nivolumab monotherapy
Successful treatment of unresectable recurrent cutaneous squamous cell carcinoma of the scalp with meningeal invasion with nivolumab monotherapy
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DOI：
10.1111/dth.13672
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发表时间：
2020-06-16
影响因子：
3.6
通讯作者：
Aiba, Setsuya
中科院分区：
文献类型：
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作者：
Fujimura, Taku;Kambayashi, Yumi;Aiba, Setsuya
尽管皮肤鳞状细胞癌(CSCC)的病例数量在增加，但系统治疗晚期CSCC的疗效有限。由于与其他肿瘤相比，CSCC具有较高的肿瘤突变负荷(TMB)，并且高TMB与新抗原的增加和抗PD1抗体(Abs)在各种癌症中的疗效相关，CSCC可能成为抗PD1抗体单药治疗的靶点。在这篇报告中，我们描述了一例无法切除的复发性头皮鳞状细胞癌脑膜侵犯，但高表达的程序性死亡配体1(PD-L1)，尼伏单抗治疗。
Although the number of cutaneous squamous cell carcinoma (cSCC) cases is increasing, the effectiveness of systemic therapy for the treatment of advanced cSCC is limited. Since cSCC possesses a high tumor mutation burden (TMB) compared to other cancer species, and since high TMB correlated with increased neoantigens and the efficacy of anti-PD1 antibodies (Abs) in various cancers, cSCC could be a target for anti-PD1 Abs monotherapy. In this report, we describe a case of unresectable recurrent cSCC of the scalp with meningeal invasion, but highly expressedprogrammed death-ligand 1(PD-L1), treated with nivolumab monotherapy.