Poorly differentiated adenocarcinoma with lymphoid stroma (lymphoepithelioma-like carcinomas) of the stomach. Report of three cases with Epstein-Barr virus genome demonstrated by the polymerase chain reaction.
Poorly differentiated adenocarcinoma with lymphoid stroma (lymphoepithelioma-like carcinomas) of the stomach. Report of three cases with Epstein-Barr virus genome demonstrated by the polymerase chain reaction.
复制标题
胃低分化腺癌伴淋巴样间质（淋巴上皮瘤样癌）。
DOI：
10.1093/ajcp/96.2.219
复制
发表时间：
1991
影响因子：
3.5
通讯作者：
Timothy J. O'Leary
中科院分区：
文献类型：
--
作者：
Kyung;Sonya Holmquist;Stephen C. Peiper;Timothy J. O'Leary
鼻咽淋巴上皮瘤是一种未分化癌，淋巴组织浸润性较强。在皮肤、肺、胸腺、唾液腺、扁桃体和子宫颈中也发现了类似的组织学肿瘤。作者报告了三例胃癌，在组织学和免疫组织化学上与淋巴上皮瘤相似。这些患者是老年白人(61岁、76岁和77岁)；其中两人曾因良性溃疡疾病接受过胃部分切除。肿瘤位于胃小弯(2例)和原吻合口(1例)，最大径分别为3、4、7 cm。大体上，每个肿瘤都是伴有中心性溃疡的隆起的斑块样病变。显微镜下，这三种肿瘤都相似，低分化的多角形肿瘤细胞散布在密集的淋巴细胞背景中。在少数区域，肿瘤细胞形成界限模糊的索状物。在两个病例中，肿瘤侵犯胃肌层，但边界清楚(推进)。肿瘤细胞的AE3角蛋白免疫组织化学染色阳性，证实了它们的上皮性。淋巴细胞由UCHL-1阳性的T细胞和L-26阳性的B细胞混合而成。通过聚合酶链式反应检测，在所有病例中都存在EB病毒基因组的一部分。这些病例的形态特征与其他解剖部位的淋巴上皮瘤相似，是胃癌的一种独特的亚型。
Lymphoepithelioma of the nasopharynx is an undifferentiated carcinoma with prominent lymphoid infiltration. Histologically similar tumors have been documented in the skin, lung, thymus, salivary gland, tonsil, and uterine cervix. The authors report three cases of gastric carcinoma that were histologically and immunohistochemically similar to lymphoepithelioma. The patients were elderly white persons (61, 76, and 77 years of age); two of them had previous partial gastric resections for benign ulcer disease. The tumors were located on the lesser gastric curvature (two cases) and at a previous anastomotic site (one case) and measured 3, 4, and 7 cm in largest dimension. Grossly, each neoplasm was a raised plaque-like lesion with a central ulcer. Microscopically, all three tumors were similar, with poorly differentiated polygonal tumor cells scattered throughout a dense lymphocytic background. In a few areas, tumor cells formed ill-defined cords. In two cases, the neoplasms invaded the gastric muscle layer but had a well-delineated (pushing) margin. The tumor cells were immunohistochemically positive for AE3-defined keratin, confirming their epithelial nature. The lymphocytes were a mixture of UCHL-1-positive T cells and L-26-positive B cells. Portions of the Epstein-Barr virus genome were present in all cases, as detected by the polymerase chain reaction. The morphologic features of these cases are similar to those of lymphoepithelioma in other anatomic sites, and these tumors represent a unique subtype of gastric carcinoma.