Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study
Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study
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DOI：
10.1016/j.cyto.2012.11.015
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发表时间：
2013-02-01
期刊：
影响因子：
3.8
通讯作者：
Mortensen, Erik L.
中科院分区：
文献类型：
--
作者：
Abdallah, Morsi W.;Larsen, Nanna;Mortensen, Erik L.
趋化因子在自闭症谱系障碍（ASD）的病理生理学中的潜在作用已经被提出。在最近的一项研究中，我们检查了晚年诊断为ASD的儿童羊水样本中三种炎症趋化因子（MCP-1、MIP-1 α和RANTES）的水平，并将对照组与性别和出生年份的病例频率相匹配。在这项后续研究中，使用丹麦新生儿筛查生物库分析了出生后来自相同受试者的干血斑样本中相同趋化因子的水平。粗略估计显示RANTES水平下降。在调整后的估计值中，与对照组相比，ASD病例中三种检测的趋化因子水平无差异。我们的研究结果可能谨慎地建议在ASD的新生儿早期细胞介导的免疫力改变。需要进一步的研究来检查母体/胎儿和新生儿趋化因子水平之间的关系及其在ASD中的作用。(c)2012爱思唯尔有限公司保留所有权利。
A potential role of chemokines in the pathophysiology of Autism Spectrum Disorders (ASDs) has been previously suggested. In a recent study we examined levels of three inflammatory chemokines (MCP-1, MIP-1 alpha and RANTES) in samples of amniotic fluid of children diagnosed later in life with ASD and controls frequency-matched to cases on gender and year of birth. In this follow-up study, levels of the same chemokines were analyzed postnatally in dried blood spot samples from the same subjects utilizing the Danish Newborn Screening Biobank. Crude estimates showed decreased levels of RANTES. In the adjusted estimates, no differences were found in levels of the three examined chemokines in ASD cases compared to controls. Our findings may cautiously suggest an altered cell-mediated immunity during the early neonatal period in ASD. Further research is needed to examine the relationship between maternal/fetal and neonatal chemokine levels and their role in ASD. (c) 2012 Elsevier Ltd. All rights reserved.