Generalized potential of adult neural stem cells
Generalized potential of adult neural stem cells
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DOI：
10.1126/science.288.5471.1660
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发表时间：
2000-06-02
期刊：
影响因子：
56.9
通讯作者：
Frisén, J
中科院分区：
文献类型：
--
作者：
Clarke, DL;Johansson, CB;Frisén, J
成体组织中干细胞的分化潜能被认为局限于其来源器官中存在的细胞谱系，但有证据表明某些干细胞可能具有更广泛的分化谱。我们在这里表明，来自成年小鼠大脑的神经干细胞可以促进嵌合鸡和小鼠胚胎的形成，并产生所有胚层的细胞。这表明成体神经干细胞具有非常广泛的发育能力，并且可能潜在地用于产生用于在不同疾病中移植的各种细胞类型。
The differentiation potential of stem ce(Ls in tissues of the adult has been thought to be Limited to cell lineages present in the organ from which they were derived, but there is evidence that some stem cells may have a broader differentiation repertoire. We show here that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers. This demonstrates that an adult neural stem cell has a very broad developmental capacity and may potentially be used to generate a variety of cell types for transplantation in different diseases.