C-terminal binding proteins (CtBPs) attenuate KLF4-mediated transcriptional activation.
C-terminal binding proteins (CtBPs) attenuate KLF4-mediated transcriptional activation.
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DOI：
10.1016/j.febslet.2009.09.013
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发表时间：
2009-10-06
期刊：
影响因子：
3.5
通讯作者：
Ai W
中科院分区：
文献类型：
--
作者：
Liu G;Zheng H;Ai W
We aimed to examine the physical interaction between CtBPs and KLF4 and the potential importance of this interaction. Co-immunoprecipitation indicated that CtBP1 indeed interacted with KLF4. This was supported by the co-localization of both KLF4 and CtBP1 in the promoter regions of KLF4 downstream target genes. In addition, overexpression of CtBP1 significantly decreased KLF4-mediated transcriptional activation in both an artificial (pGL5) and genuine (IAP and Keratin-4) reporter system. Mutations in the potential CtBP binding motif in KLF4 were accompanied by loss of the inhibitory effect of CtBP1 in the reporter assay and of the physical interaction with CtBP1. Overall, our results suggest that CtBPs attenuate KLF4-mediated transcriptional activation through the physical interaction with KLF4.
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影响因子：
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DOI：
10.1073/pnas.92.23.10467
发表时间：
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影响因子：
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