Impedance characterization and modeling of electrodes for biomedical applications
Impedance characterization and modeling of electrodes for biomedical applications
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DOI：
10.1109/tbme.2005.847523
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发表时间：
2005-07-01
影响因子：
4.6
通讯作者：
Hierlemann, A
中科院分区：
文献类型：
--
作者：
Franks, W;Schenker, I;Hierlemann, A
在生物医学电极的设计中，低电极-电解质阻抗界面是至关重要的。要设计低阻抗接口，需要对构成阻抗的物理过程有全面的了解。在这项工作中，一个描述这些物理过程的模型被验证和扩展，以量化有机涂层和孵化时间的影响。电化学阻抗谱已经被用来对各种电极材料的界面进行电学表征：铂、铂黑和氮化钛；以及不同的电极尺寸：1厘米(2)和900微米(2)。由电荷转移电阻串联的界面电容与溶液电阻串联而成的等效电路模型与实验结果相吻合。用理论公式计算了界面电容阻抗和溶液电阻，得到了与拟合参数值吻合较好的结果，从而证实了公式的有效性。利用该模型定量了孵育时间和两种有机细胞黏附促进涂层--多L赖氨酸和层粘连蛋白对界面阻抗的影响。这证明了在更复杂、生物医学相关的情况下，使用该模型更好地理解在界面上发生的物理过程的好处。
A low electrode-electrolyte impedance interface is critical in the design of electrodes for biomedical applications. To design low-impedance interfaces a complete understanding of the physical processes contributing to the impedance is required. In this work a model describing these physical processes is validated and extended to quantify the effect of organic coatings and incubation time. Electrochemical impedance spectroscopy has been used to electrically characterize the interface for various electrode materials: platinum, platinum black, and titanium nitride; and varying electrode sizes: 1 cm(2), and 900 mu m(2). An equivalent circuit model comprising an interface capacitance, shunted by a charge transfer resistance, in series with the solution resistance has been fitted to the experimental results. Theoretical equations have been used to calculate the interface capacitance impedance and the solution resistance, yielding results that correspond well with the fitted parameter values, thereby confirming the validity of the equations. The effect of incubation time, and two organic cell-adhesion promoting coatings, poly-L-lysine and laminin, on the interface impedance has been quantified using the model. This demonstrates the benefits of using this model in developing a better understanding of the physical processes occurring at the interface in more complex, biomedically relevant situations.