Chromatin assembly. Cooperation between histone chaperones and ATP-dependent nucleosome remodeling machines.
Chromatin assembly. Cooperation between histone chaperones and ATP-dependent nucleosome remodeling machines.
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DOI：
10.1046/j.1432-1033.2002.02890.x
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发表时间：
2002-05
期刊：
影响因子：
--
通讯作者：
J. Tyler
中科院分区：
文献类型：
--
作者：
J. Tyler
染色质是一种高度动态的结构，在调节所有利用DNA模板的核过程中起着重要作用，包括DNA修复，复制，转录和重组。因此，染色质结构组装和修饰的机制是广泛关注的问题。这篇小综述将集中在两组蛋白质：（a）组蛋白伴侣蛋白和（B）ATP依赖的染色质重塑机器，合作组装DNA和组蛋白进入染色质。目前的理解如何组蛋白伴侣和ATP依赖的重塑机器协调组装染色质在体外将进行讨论，连同越来越多的遗传证据，支持组蛋白伴侣在细胞中的作用。
Chromatin is a highly dynamic structure that plays an essential role in regulating all nuclear processes that utilize the DNA template including DNA repair, replication, transcription and recombination. Thus, the mechanisms by which chromatin structures are assembled and modified are questions of broad interest. This minireview will focus on two groups of proteins: (a) histone chaperones and (b) ATP-dependent chromatin remodeling machines, that co-operate to assemble DNA and histone proteins into chromatin. The current understanding of how histone chaperones and ATP-dependent remodeling machines coordinately assemble chromatin in vitro will be discussed, together with the growing body of genetic evidence that supports the role of histone chaperones in the cell.