Targeting cancer stem cells as therapeutic approach in the treatment of colorectal cancer
Targeting cancer stem cells as therapeutic approach in the treatment of colorectal cancer
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DOI：
10.1016/j.biocel.2019.02.010
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发表时间：
2019-05-01
影响因子：
4
通讯作者：
Avan, Amir
中科院分区：
文献类型：
--
作者：
Parizadeh, Seyed Mostafa;Jafarzadeh-Esfehani, Reza;Avan, Amir
结直肠癌是全球最常见的癌症之一。大部分接受常规化疗的结直肠癌患者最终会出现局部复发或转移。结直肠癌患者未能完全治愈可能与使用常规治疗时未能完全根除癌症干细胞有关。结直肠癌干细胞由一小群肿瘤细胞组成，具有快速增殖和分化的特性。结直肠癌干细胞也是表型和分子上不同的，并且对常规化学-放射疗法具有抗性。因此，重要的是要确定与常规疗法相结合的方法，用于靶向和根除癌细胞。本文综述了近年来以大肠癌干细胞为靶点治疗大肠癌的研究进展。
Colorectal cancer is one of the most common cancers globally. A large portion of colorectal cancer patients who are treated with conventional chemotherapy eventually develop local recurrence or metastases. The failure of a complete cure in colorectal cancer patients may be related to the lack of complete eradication of cancer stem cells when using conventional therapy. Colorectal cancer stem cells comprise a small population of tumor cells that possess the properties of rapid proliferation and differentiation. The colorectal cancer stem cells are also phenotypically and molecularly distinct, and resistant to conventional chemo-radiotherapy. Therefore, it is important to identify approaches in combination with conventional therapy for targeting and eradicating cancer cells. The aim of this review was to summarize the main findings of recent studies on targeting colorectal cancer stem cells as a novel therapeutic approach in colorectal cancer treatment.