Lung cancer stem cells: Molecular features and therapeutic targets.
Lung cancer stem cells: Molecular features and therapeutic targets.
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DOI：
10.1016/j.mam.2013.08.003
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发表时间：
2014-10
影响因子：
10.6
通讯作者：
Chellappan, Srikumar
中科院分区：
文献类型：
--
作者：
Singh, Sandeep;Chellappan, Srikumar
肺癌具有高度异质性，对现有治疗药物具有耐药性，五年生存率不到15%。尽管我们在对基因改变以及信号通路异常的认识方面取得了重大进展，但一直难以确定肺癌异质性和耐药性的基础。近年来，癌症干细胞模型作为对各种肿瘤的异质性、耐药性、休眠以及复发和转移的一种合理的解释，受到了极大关注。同时，肺癌中的癌症干细胞相对来说特征描述较少。这篇综述总结了目前对肺癌干细胞的认识，包括驱动其干性的分子特征和信号通路。这篇综述还讨论了抑制驱动干性的信号通路的潜在策略，以努力根除这些细胞来对抗肺癌。
Lung cancers are highly heterogeneous and resistant to available therapeutic agents, with a five year survival rate of less than 15%. Despite significant advances in our knowledge of the genetic alterations and aberrations in signaling pathways, it has been difficult to determine the basis of lung cancer heterogeneity and drug ressitance. Cancer stem cell model has attracted a significant amount of attention in recent years as a viable explanation for the heterogeneity, drug resistance, dormancy and recurrence and metastasis of various tumors. At the same time, cancer stem cells have been relatively less characetrized in lung cancers. This review summarizes the current understanding of lung cancer stem cells, including their molecular features and signaling pathways that drive their stemness. This review also discusses the potential startegies to inhibit the signaling pathways driving stemness, in an effort to eradicate these cells to combat lung cancer.
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影响因子：
3.7
作者：
Barr MP;Gray SG;Hoffmann AC;Hilger RA;Thomale J;O'Flaherty JD;Fennell DA;Richard D;O'Leary JJ;O'Byrne KJ
通讯作者：
O'Byrne KJ
影响因子：
8
作者：
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通讯作者：
Carbone, DP
DOI：
10.1073/pnas.0603806103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Chute, John P.;Muramoto, Garrett G.;McDonnell, Donald P.
通讯作者：
McDonnell, Donald P.
影响因子：
30.8
作者：
Bass, Adam J.;Watanabe, Hideo;Mermel, Craig H.;Yu, Soyoung;Perner, Sven;Verhaak, Roel G.;Kim, So Young;Wardwell, Leslie;Tamayo, Pablo;Gat-Viks, Irit;Ramos, Alex H.;Woo, Michele S.;Weir, Barbara A.;Getz, Gad;Beroukhim, Rameen;O'Kelly, Michael;Dutt, Amit;Rozenblatt-Rosen, Orit;Dziunycz, Piotr;Komisarof, Justin;Chirieac, Lucian R.;LaFargue, Christopher J.;Scheble, Veit;Wilbertz, Theresia;Ma, Changqing;Rao, Shilpa;Nakagawa, Hiroshi;Stairs, Douglas B.;Lin, Lin;Giordano, Thomas J.;Wagner, Patrick;Minna, John D.;Gazdar, Adi F.;Zhu, Chang Qi;Brose, Marcia S.;Cecconello, Ivan;Ribeiro, Ulysses, Jr.;Marie, Suely K.;Dahl, Olav;Shivdasani, Ramesh A.;Tsao, Ming-Sound;Rubin, Mark A.;Wong, Kwok K.;Regev, Aviv;Hahn, William C.;Beer, David G.;Rustgi, Anil K.;Meyerson, Matthew
通讯作者：
Meyerson, Matthew
DOI：
10.1073/pnas.1102454108
发表时间：
2011-05-10
影响因子：
11.1
作者：
Chaffer, Christine L.;Brueckmann, Ines;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.