Prenatal cocaine exposure increases anxiety, impairs cognitive function and increases dendritic spine density in adult rats: influence of sex.
Prenatal cocaine exposure increases anxiety, impairs cognitive function and increases dendritic spine density in adult rats: influence of sex.
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DOI：
10.1016/j.neuroscience.2010.04.067
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发表时间：
2010-09-01
期刊：
影响因子：
3.3
通讯作者：
Friedman, E.
中科院分区：
文献类型：
--
作者：
Salas-Ramirez, K. Y.;Frankfurt, M.;Alexander, A.;Luine, V. N.;Friedman, E.
怀孕期间接触可卡因会影响大脑发育，并产生长期的行为后果。本研究考察了孕期接触可卡因(PN-COC)对成年雄性和雌性大鼠认知任务表现和树突棘密度的持久影响。从妊娠第8天到第20天，每天给予30 mg/kg(Ip)的可卡因盐酸盐或生理盐水。在62日龄时，对仔鼠进行焦虑、运动、视觉记忆和空间记忆的连续测试。接触PN-COC显著增加了两性的焦虑。使用物体再认(OR)和放置(OP)任务评估认知功能。行为测试由探索试验(T1)和认知试验(T2)组成，这两个试验之间有不同长度的试验间延迟。在OR和OP任务中，男性PN-COC受试者在T2时间段内研究新物体或物体位置的时间显著减少。相比之下，女性PN-COC受试者仅在OR中表现出损害，并且仅在最长的试验间延迟间隔表现出损害。此外，孕期可卡因增加了前额叶皮质和伏隔核中的树突密度，但只有女性的海马区CA1区的树突密度增加。这些数据表明，宫内暴露于可卡因会导致成年后焦虑、认知功能和脊柱密度的持久变化。此外，男性的认知缺陷比女性更严重。
Cocaine exposure during pregnancy can impact brain development and have long-term behavioral consequences. The present study examined the lasting consequences of prenatal cocaine (PN-COC) exposure on the performance of cognitive tasks and dendritic spine density in adult male and female rats. From gestational day 8 to 20, dams were treated daily with 30 mg/kg (ip) of cocaine HCl or saline. At 62 days of age, offspring were tested consecutively for anxiety, locomotion, visual memory and spatial memory. PN-COC exposure significantly increased anxiety in both sexes. Object recognition (OR) and placement (OP) tasks were used to assess cognitive function. Behavioral tests consisted of an exploration trial (T1) and a recognition trial (T2) that were separated by an inter-trial delay of varying lengths. Male PN-COC subjects displayed significantly less time investigating new objects or object location during T2 in both OR and OP tasks. By contrast, female PN-COC subjects exhibited impairments only in OR and only at the longest inter-trial delay interval. In addition, gestational cocaine increased dendritic spine density in the prefrontal cortex and nucleus accumbens in both genders, but only females had increased spine density in the CA1 region of the hippocampus. These data reveal that in-utero exposure to cocaine results in enduring alterations in anxiety, cognitive function and spine density in adulthood. Moreover, cognitive deficits were more profound in males than in females.
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DOI：
10.1016/0165-3806(90)90052-z
发表时间：
1990-12-15
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
DOWEDWARDS, DL;FREED, LA;FICO, TA
通讯作者：
FICO, TA
影响因子：
2.3
作者：
Glatt, SJ;Trksak, GH;Jackson, D
通讯作者：
Jackson, D
影响因子：
2.9
作者：
BILITZKE, PJ;CHURCH, MW
通讯作者：
CHURCH, MW
DOI：
10.1111/j.1749-6632.1998.tb09741.x
发表时间：
1998-01-01
期刊：
COCAINE: EFFECTS ON THE DEVELOPING BRAIN
影响因子：
--
作者：
Friedman, E;Wang, HY
通讯作者：
Wang, HY
影响因子：
2.9
作者：
Frankfurt, Maya;Wang, Hoau-Yan;Friedman, Eitan
通讯作者：
Friedman, Eitan