Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function.
Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function.
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DOI：
10.3389/fnmol.2015.00075
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发表时间：
2015
影响因子：
4.8
通讯作者：
Puighermanal E
中科院分区：
文献类型：
--
作者：
Biever A;Valjent E;Puighermanal E
自从大约40年前发现40S核糖体蛋白S6(RpS6)的磷酸化以来，人们一直在努力揭示这种翻译后修饰调控的分子机制。在神经科学领域，rpS6的磷酸化通常被用来读出哺乳动物雷帕霉素复合体1信号激活的靶点或作为神经元活性的标志。然而，它在神经元中的生物学作用仍然令人困惑。在这里，我们回顾了在神经系统中调节这种修饰的药理和生理刺激，以及将这些信号转导到rpS6磷酸化的途径。还讨论了在不同的遗传和病理生理模型中观察到的改变的rpS6磷酸化。最后，我们考察了关于这种翻译后修饰的生理作用的知识现状，并强调了有待解决的问题。
Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four decades ago, much effort has been made to uncover the molecular mechanisms underlying the regulation of this post-translational modification. In the field of neuroscience, rpS6 phosphorylation is commonly used as a readout of the mammalian target of rapamycin complex 1 signaling activation or as a marker for neuronal activity. Nevertheless, its biological role in neurons still remains puzzling. Here we review the pharmacological and physiological stimuli regulating this modification in the nervous system as well as the pathways that transduce these signals into rpS6 phosphorylation. Altered rpS6 phosphorylation observed in various genetic and pathophysiological mouse models is also discussed. Finally, we examine the current state of knowledge on the physiological role of this post-translational modification and highlight the questions that remain to be addressed.