Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness
Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness
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DOI：
10.1073/pnas.1017069108
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发表时间：
2010-12-28
影响因子：
11.1
通讯作者：
Kopell, Nancy J.
中科院分区：
文献类型：
--
作者：
Ching, ShiNung;Cimenser, Aylin;Kopell, Nancy J.
近期数据显示，全身麻醉剂异丙酚在足以导致意识丧失的剂量水平下会引发额叶α节律。在这项研究中，开发了一个计算模型，该模型揭示了产生这种节律的网络机制。研究表明，异丙酚能够改变丘脑皮质环路的动态，导致持续性和同步性的α活动。由于丘脑的参与而在皮质中形成的同步性可能会阻碍对外界刺激的反应，从而为无意识状态提供了一种相关联的解释。
Recent data reveal that the general anesthetic propofol gives rise to a frontal alpha-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous alpha-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.