HLA‐Linked Genes Controlling Immune Response and Disease Susceptibility 1
HLA‐Linked Genes Controlling Immune Response and Disease Susceptibility 1
复制标题
控制免疫反应和疾病易感性的 HLA 相关基因 1
作者：
T. Sasazuki;Yasuharu Nrshimura;M. Muto;N. Ohta
自从 McDevitt 和 Benacerraf 在小鼠和豚鼠中描述了主要组织相容性复合物 (MHC) 相关的免疫反应基因 (/r-基因) (McDevitt & Chinitz 1969, Benacerraf & McDevitt 1972, McDevitt & Benacerraf 1969)，人们普遍认为 HLA 相关的 /r-基因或 HLA 相关免疫 人类中存在抑制基因（/j'-基因）。许多研究人员使用这一未经证实的假设来解释他们发现的 HLA 与疾病之间统计关联的机制。在本文中，我们提供了 HLA 相关 /j 基因的存在及其在自身免疫性疾病和过敏发病机制中的关键作用的明确证据。
Ever since the major histocompatibility complex (MHC)-linked immune response genes (/r-genes) were described by McDevitt and Benacerraf in mice and guinea pigs (McDevitt & Chinitz 1969, Benacerraf & McDevitt 1972, McDevitt & Benacerraf 1969), it has been widely assumed that the HLA-linked /r-genes or HLA-linked immune suppression genes (/j'-genes) exist in humans. This unproven hypothesis has been used by many investigators to explain the mechanisms of their fmdings of statistical association between HLA and diseases. In this paper we present clear evidence for the existence of HLA-linked /j-genes and their crucial roles in pathogenesis of autoimmune disease and allergy.