SEX-HORMONE LEVELS IN SERUM IN RELATION TO THE DEVELOPMENT OF BREAST-CANCER
SEX-HORMONE LEVELS IN SERUM IN RELATION TO THE DEVELOPMENT OF BREAST-CANCER
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DOI：
10.1093/oxfordjournals.aje.a114596
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发表时间：
1987-05-01
影响因子：
5
通讯作者：
LAU, HL
中科院分区：
文献类型：
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作者：
WYSOWSKI, DK;COMSTOCK, GW;LAU, HL
1974年，马里兰州华盛顿县的大约13，000名女性居民捐献了15 ml血液，作为确定某些血清学因素是否与特定部位癌症的发展有关的项目的一部分。将血清储存在-73 ℃。本研究报告了17例在抽血后8-132个月诊断的绝经前病例和39例在抽血后6-72个月诊断的绝经后病例中血清雌酮、雌二醇、雌三醇、雄烯二酮、孕酮和睾酮水平与乳腺癌的关系。每个病例与从其他血清库供体中选择的四个对照匹配。匹配因素包括年龄、种族和距上次月经的时间。正在服用含雌激素制剂的病例和对照组被排除在本分析之外。在不了解病例对照状态的情况下分析血清。病例组与对照组血清激素水平差异轻微，无统计学意义。
In 1974, approximately 13,000 female residents of Washington County, Maryland, donated 15 ml of blood as part of a project to determine if certain serologic factors were related to the development of site-specific cancer. Sera were stored at -73 C. The present study reports the associations of serum levels of estrone, estradiol, estriol, androstenedione, progesterone, and testosterone with breast cancer among 17 premenopausal cases diagnosed 8-132 months after blood was drawn, and 39 postmenopausal cases diagnosed 6-72 months after blood was drawn. Each case was matched to four controls selected from the other serum bank donors. Matching factors were age, race, and time since last menstrual period. Cases and controls who were taking estrogen-containing preparations were excluded from this analysis. Sera were analyzed without knowledge of case-control status. Differences in levels of serum hormones between cases and controls were slight and not statistically significant.