Neuroendocrine responses to experimentally-induced emotions among abstinent opioid-dependent subjects
Neuroendocrine responses to experimentally-induced emotions among abstinent opioid-dependent subjects
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DOI：
10.1016/s0376-8716(03)00065-6
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发表时间：
2003-07-20
影响因子：
4.2
通讯作者：
Brambilla, F
中科院分区：
文献类型：
--
作者：
Gerra, G;Baldaro, B;Brambilla, F
本研究探讨了海洛因依赖者在实验诱导的情感状态下的神经内分泌和心血管变化。健康的对照。在所有受试者中引发情绪的过程中，使用了在主观唤醒特性上没有差异的愉快和不愉快的刺激。通过比较中性、愉快和不愉快的图片对心率（HR）、收缩压（SBP）和舒张压（DBP）、甲基-OH-苯乙二醇（MHPG）、去甲肾上腺素（NE）、肾上腺素（EPI）、促肾上腺皮质激素（ACTH）和皮质醇（CORT）血浆水平的影响，我们研究了刺激的效价是否差异地影响神经内分泌反应。12名戒断海洛因依赖者与12名对照组受试者进行了三次实验，每一次都在每周三个实验日中的一天进行，按平衡顺序进行：第1天=不愉快的图片，第2天=愉快的图片，第3天=中性图片。在主观唤醒的评级愉快和不愉快的刺激收到相同的高分相比，中性刺激，不同的心血管和神经内分泌模式，在健康受试者：不愉快的刺激引起增加HR，SBP，MHPG，NE，ACTH，CORT，而中性和愉快的刺激没有引起任何显着的反应激素水平。与此相反，在海洛因成瘾者，尽管增加了不愉快的感觉，HR，SBP，MHPG和NE水平并没有增加后不喜欢的刺激，这些科目也报告增加唤醒暴露于中性刺激。与对照组相比，成瘾者表现出更高的CORT和ACTH基础水平，因此缺乏对不愉快刺激的反应。结果表明，神经内分泌和心血管系统选择性地响应情感，动机相关的刺激，物质使用障碍可能与情绪处理机制失调。(C)2003爱思唯尔科学爱尔兰有限公司保留所有权利。
The present study investigated neuroendocrine and cardiovascular changes during experimentally-induced affective states in abstinent heroin-dependent subjects. and healthy controls. The procedure for eliciting emotions in all subjects used pleasant and unpleasant stimuli that did not differ in subjective arousal properties. We investigated whether the valence of the stimuli differentially affected neuroendocrine responses by comparing neutral, pleasant and unpleasant pictures on heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP), methyl-OH-phenyl-glycol (MHPG), norepinephrine (NE), epinephrine (EPI), adrenocorticotrophic hormone (ACTH) and cortisol (CORT) plasma levels. Twelve abstinent heroin-dependent subjects, in comparison with 12 control subjects, were submitted to three experimental sessions, each on one of three experimental days a week apart, in counterbalanced order: day 1 = unpleasant pictures, day 2 = pleasant pictures, day 3 = neutral pictures. In the rating of subjective arousal pleasant and unpleasant stimuli received the same high score in comparison with neutral stimuli; a different cardiovascular and neuroendocrine pattern was obtained in healthy subjects: unpleasant stimuli elicited increases in HR, SBP, MHPG, NE, ACTH, CORT, whereas neutral and pleasant stimuli did not induce any significant response in hormonal levels. In contrast, in heroin addicts, despite increased perceptions of unpleasantness, HR, SBP, MHPG and NE levels did not increase after disliked stimuli; these subjects also reported increased arousal during exposure to neutral stimuli. In comparison with controls, addicted individuals showed higher CORT and ACTH basal levels, and a consequent lack of response to unpleasant stimuli. The results indicate that neuroendocrine and cardiovascular systems respond selectively to affective, motivationally relevant stimuli, and that substance use disorders may be associated with dysregulation of emotion-processing mechanisms. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.