Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm.
Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm.
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DOI：
10.3389/fcvm.2017.00016
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发表时间：
2017
影响因子：
3.6
通讯作者：
Golledge J
中科院分区：
文献类型：
--
作者：
Emeto TI;Alele FO;Smith AM;Smith FM;Dougan T;Golledge J
腹主动脉瘤（AAA）是一种主动脉退行性疾病，常见于65岁以上成人。AAA通常使用超声或计算机断层扫描成像。采用纳米颗粒（NPs）的分子成像技术已被提出作为量化AAAs内病理过程（如炎症）的新方法，作为识别快速进展或破裂风险的一种手段。本文回顾了目前支持基于np的成像在AAA治疗中的作用的证据。目前，超顺磁性NPs增强磁共振成像似乎在人类AAA中巨噬细胞介导的炎症成像方面具有最大的潜力。
Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta common in adults older than 65 years of age. AAA is usually imaged using ultrasound or computed tomography. Molecular imaging technologies employing nanoparticles (NPs) have been proposed as novel ways to quantify pathological processes, such as inflammation, within AAAs as a means to identify the risk of rapid progression or rupture. This article reviews the current evidence supporting the role of NP-based imaging in the management of AAA. Currently, ultrasmall superparamagnetic NPs enhanced magnetic resonance imaging appears to hold the greatest potential for imaging macrophage-mediated inflammation in human AAA.