Sustained heart failure induced by repeated microsphere injections for left ventricular assist device testing.
Sustained heart failure induced by repeated microsphere injections for left ventricular assist device testing.
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DOI：
10.1097/00002480-198907000-00092
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发表时间：
1989-07-01
期刊：
影响因子：
--
通讯作者：
Losert, U
中科院分区：
文献类型：
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作者：
Moritz, A;Fujimoto, L K;Losert, U
建立了一个亚急性至慢性心力衰竭模型，以测试左心室辅助装置（LVAD）系统。对5头小牛进行麻醉和器械化。通过每天将聚苯乙烯微球（37-70微米）注射到左冠状动脉导管中来诱导心力衰竭。最后3只动物植入了心房-主动脉搏动LVAD。心输出量（CO）从12 L/min降至5.5 L/min，SV从120 ml降至60 ml，而左房压（mmHg）在10至20天内从12升至25 mmHg。两只动物都停止了进食和饮水。LVAD实验在5、10和11天后终止。在每日停泵试验期间测定心脏功能。在重复微球注射后，在没有泵支持的情况下，CO2增加到30和50 mmHg，CO降低到4和6 L/min。每日逐步微球注射以安全可靠的方式诱导硬化性心肌病。
A subacute to chronic heart failure model was established to test left ventricular assist device (LVAD) systems. Five calves were anesthetized and instrumented. Heart failure was induced by daily injection of polystyrene microspheres (37-70 microns) into a left coronary catheter. The last three animals had an atrio-aortic pulsatile LVAD implanted. Cardiac output (CO) decreased from 12 to 5.5 L/min, and SV from 120 to 60 ml, whereas left atrial pressure (LAP) increased from 12 to 25 mmHg within 10 to 20 days in the two animals without LVAD support. Both animals stopped eating and drinking. The LVAD experiments were terminated after 5, 10, and 11 days. Cardiac function was determined during daily pump-off tests. After repeated microsphere injections, LAP increased to 30 and 50 mmHg, and CO decreased to 4 and 6 L/min without pump support. Daily stepwise microsphere injections induce a sclerotic cardiomyopathy in a safe and reliable manner.