Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19).
Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19).
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DOI：
10.4014/jmb.2003.03011
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发表时间：
2020-03-28
影响因子：
2.8
通讯作者：
Kim SJ
中科院分区：
文献类型：
--
作者：
Ahn DG;Shin HJ;Kim MH;Lee S;Kim HS;Myoung J;Kim BT;Kim SJ
2019年冠状病毒病（COVID-19），导致严重的呼吸道疾病，如肺炎和肺衰竭，首次在中国湖北的省会武汉市报告。COVID-19的病原体已被确认为一种新型冠状病毒，现在称为严重急性呼吸综合征冠状病毒2（SARS-CoV-2），它最有可能起源于人畜共患冠状病毒，如2002年出现的SARS-CoV。在第一次报告的几个月内，SARS-CoV-2在中国和世界范围内传播，达到了大流行的水平。由于COVID-19引发了巨大的人类伤亡和严重的经济损失，构成全球威胁，因此迫切需要了解当前形势并制定遏制病毒传播的策略。目前，可获得用于测试COVID-19的各种诊断试剂盒，并且用于COVID-19的几种再利用疗法已被证明是临床有效的。此外，全球机构及公司已开始研发预防COVID-19的疫苗。在这里，我们回顾了COVID-19的流行病学、诊断、治疗和疫苗开发的现状。
Coronavirus disease 2019 (COVID-19), which causes serious respiratory illness such as pneumonia and lung failure, was first reported in Wuhan, the capital of Hubei, China. The etiological agent of COVID-19 has been confirmed as a novel coronavirus, now known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is most likely originated from zoonotic coronaviruses, like SARS-CoV, which emerged in 2002. Within a few months of the first report, SARS-CoV-2 had spread across China and worldwide, reaching a pandemic level. As COVID-19 has triggered enormous human casualties and serious economic loss posing global threat, an understanding of the ongoing situation and the development of strategies to contain the virus’s spread are urgently needed. Currently, various diagnostic kits to test for COVID-19 are available and several repurposing therapeutics for COVID-19 have shown to be clinically effective. In addition, global institutions and companies have begun to develop vaccines for the prevention of COVID-19. Here, we review the current status of epidemiology, diagnosis, treatment, and vaccine development for COVID-19.