Time dependence of airways and lung parenchymal recoil hysteresis.
Time dependence of airways and lung parenchymal recoil hysteresis.
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气道和肺实质反冲滞后的时间依赖性。
DOI：
10.1152/jappl.1986.61.1.248
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Lowe,JE
中科院分区：
文献类型：
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作者：
Fairshter,RD;Berry,RB;Wilson,AF;Lowe,JE
通过测量正常人深吸气（DI）前和深吸气后5、10、15和30 s的比电导（sGaw）和肺弹性回缩（Pst，L）来检测气道和肺实质回缩的滞后性。吸入异丙肾上腺素前后常规肺功能检查均正常。sGaw在DI后10 s显著增加。此外，在DI后5、10、15和30 s，sGaw（DI）分别在12例受试者中的11例、12例受试者中的8例、12例受试者中的7例和12例受试者中的6例大于sGaw。sGaw对DI和异丙肾上腺素的反应相互之间具有显著相关性（r = 0.82，P <0.001）。然而，在使用异丙肾上腺素后，sGaw（DI）未超过sGaw。Pst，L在DI后15 s显著降低，最低Pst，L（DI）值出现在DI后5 s（P <0.01-0.001）。sGaw（DI）和Pst，L（DI）值均以时间依赖性指数方式恢复至基线（吸气前），时间常数分别为9.2 +/- 4.9和11.3 +/- 6.1 s;这些时间常数彼此无显著差异。我们的结论是，气道滞后是主要的发现在正常受试者（即使没有事先药理支气管收缩）之前，但不是后metaproterenol; Pst，L DI后下降，并在正常人，返回到基线在一个时间依赖性的方式;和时间依赖性行为的气道和肺实质滞后有相反的（和不平等的）影响气道口径。
Hysteresis of airways and lung parenchymal recoil was examined in normal subjects by measuring specific conductance (sGaw) and lung elastic recoil (Pst,L) before and 5, 10, 15, and 30 s after deep inspiration (DI). Routine lung function tests were normal before and after inhaled metaproterenol. sGaw increased significantly for 10 s after DI. Also, sGaw(DI) was greater than sGaw in 11 of 12, 8 of 12, 7 of 12, and 6 of 12 subjects at 5, 10, 15, and 30 s, respectively, after DI. The response of sGaw to DI and metaproterenol correlated significantly with each other (r = 0.82, P less than 0.001). However, after metaproterenol, sGaw(DI) did not exceed sGaw. Pst,L decreased significantly for 15 s after DI, with the lowest measured Pst,L(DI) values occurring 5 s after DI (P less than 0.01–0.001). Both sGaw(DI) and Pst,L(DI) values returned to base line (preinspiration) in a time-dependent exponential manner, with time constants of 9.2 +/- 4.9 and 11.3 +/- 6.1 s, respectively; these time constants were not significantly different from each other. We conclude that airways hysteresis is the predominant finding in normal subjects (even without prior pharmacological bronchoconstriction) before but not after metaproterenol; Pst,L decreases after DI and, in normal individuals, returns to base line in a time-dependent manner; and the time-dependent behavior of airways and lung parenchymal hysteresis have opposite (and unequal) effects on airway caliber.