Antigen-specific T cell Sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
Antigen-specific T cell Sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
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DOI：
10.1016/s1074-7613(02)00391-6
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发表时间：
2002-09-01
期刊：
影响因子：
32.4
通讯作者：
Iwakura, Y
中科院分区：
文献类型：
--
作者：
Nakae, S;Komiyama, Y;Iwakura, Y
白细胞介素-17（IL-17）是由T细胞产生的促炎细胞因子。IL-17在哮喘患者血清和关节炎患者滑液中的检测结果表明，IL-17与人类疾病有关。在这项研究中，我们产生了IL-17缺陷小鼠，并研究了IL-17在各种疾病模型中的作用。我们发现，接触，迟发型，气道过敏反应，以及T依赖性抗体的产生，显着减少突变小鼠，而IL-17缺乏供体T细胞不影响急性移植物抗宿主反应。结果表明，受损的反应是由过敏原特异性T细胞活化缺陷引起的。我们的研究结果表明，IL-17在激活T细胞在过敏原特异性T细胞介导的免疫反应中起着重要作用。
Interleukin-17 (IL-17) is a proinflammatory cytokine produced by T cells. The involvement of IL-17 in human diseases has been suspected because of its detection in sera from asthmatic patients and synovial fluids from arthritic patients. In this study, we generated IL-17-deficient mice and investigated the role of IL-17 in various disease models. We found that contact, delayed-type, and airway hypersensitivity responses, as well as T-dependent antibody production, were significantly reduced in the mutant mice, while IL-17 deficiency of donor T cells did not affect acute graft-versus-host reaction. The results suggest that impaired responses were caused by the defects of allergen-specific T cell activation. Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses.