Aerosol deposition and clearance in the human upper airways.
Aerosol deposition and clearance in the human upper airways.
复制标题
人体上呼吸道中的气溶胶沉积和清除。
DOI：
10.1007/bf02364773
复制
发表时间：
1981
影响因子：
3.8
通讯作者：
Swift,DL
中科院分区：
文献类型：
--
作者：
Swift,DL
人的上呼吸道，这里定义为气管上方的气道，是空气中微粒进入的门户。吸入颗粒是否到达支气管或肺泡气道或沉积在上呼吸道（鼻腔或口腔通道）取决于本文讨论的许多因素。这些因素可分为两组：与空气流动特性有关的因素和与颗粒有关的因素。如果这些因素已知足够的程度，就可以估计吸入颗粒的区域沉积效率。颗粒一旦沉积在上呼吸道，就会根据颗粒的类型、沉积位置和气道表面的功能状态，通过几种机制之一被清除。讨论了各种颗粒的清除过程及其重要性。
The human upper respiratory tract, defined here as the airways above the trachea, is the portal of entry for airborne particles. Whether inhaled particles reach the bronchial or alveolated airways or are deposited in the upper airways (nasal or oral passage) depends upon a number of factors which are discussed in this paper. These factors can be divided into two groups: those which relate to the air flow properties and those which relate to the particles. If these factors are known to a sufficient degree, the regional deposition efficiency of the inhaled particles can be estimated. Particles once deposited in the upper airway are cleared by one of several mechanisms depending on the type of particle, site of deposition and functional state of the airway surface. The clearance processes and their importance for various particles are discussed.