Laterality in functional brain imaging studies of schizophrenia.
Laterality in functional brain imaging studies of schizophrenia.
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DOI：
10.1093/oxfordjournals.schbul.a033361
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发表时间：
1999
影响因子：
6.6
通讯作者：
R. E. Gur;Samuel Chin
中科院分区：
文献类型：
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作者：
R. E. Gur;Samuel Chin
精神分裂症的大脑偏侧性已通过功能神经影像学方法的应用进行了检查。这些方法包括用于测量脑血流量 (CBF) 的 133Xenon 技术；正电子发射断层扫描用于评估葡萄糖代谢率、CBF 和神经受体功能；用于研究 CBF 和神经感受器的单光子发射计算机断层扫描；以及功能性磁共振成像，用于测量 CBF 引起的变化。本文重点介绍了该技术在精神分裂症研究中的应用，强调了最近评估半球差异的研究。在一些研究这个维度的研究中，有证据表明存在偏侧异常。一般来说，结果表明左半球活动异常。基础和临床神经科学的最新进展为功能成像在精神分裂症神经生物学研究中的集中应用提供了机会。
Brain laterality in schizophrenia has been examined through the application of functional neuroimaging methods. These methods have included the 133Xenon technique for measuring cerebral blood flow (CBF); positron emission tomography for assessing rates of glucose metabolism, CBF, and neuroreceptor functioning; single photon emission computerized tomography for studying CBF and neuroreceptors; and functional magnetic resonance imaging for measuring changes attributable to CBF. This article highlights the application of this technology in schizophrenia research, emphasizing more recent studies that have evaluated hemispheric differences. There is evidence for lateralized abnormalities in some studies that have examined this dimension. In general, the results implicate abnormalities in left hemispheric activity. Recent advances in basic and clinical neuroscience provide an opportunity for focused application of functional imaging in neurobiological studies of schizophrenia.