Rhodium-Catalyzed [3+2] Annulation of Indoles
Rhodium-Catalyzed [3+2] Annulation of Indoles
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DOI：
10.1021/ja9078094
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发表时间：
2010-01-20
影响因子：
15
通讯作者：
Davies, Huw M. L.
中科院分区：
文献类型：
--
作者：
Lian, Yajing;Davies, Huw M. L.
发展了一种有效的Rh-2(S-DOSP)(4)催化的吲哚环不对称环戊化反应。这取决于吲哚的取代模式。可以产生两种不同的区域异构体产物。这些研究表明，通过两性离子中间体进行的Rh催化的给体/受体卡宾的反应可以在很高的不对称诱导下进行。
An effective Rh-2(S-DOSP)(4)-catalyzed asymmetric cyclopentannulation of indolyl rings has been developed. Depending on the Substitution pattern of the indole. two distinct regioisomeric products can be generated. These studies demonstrate that rhodium-catalyzed reactions of donor/acceptor carbenoids proceeding by means of zwitterionic intermediates can be carried out with very high asymmetric induction.