Assessment of cerebral autoregulation using time-domain cross-correlation analysis
Assessment of cerebral autoregulation using time-domain cross-correlation analysis
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DOI：
10.1016/s0010-4825(01)00015-4
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发表时间：
2001-11-01
影响因子：
7.7
通讯作者：
Yeh, SJ
中科院分区：
文献类型：
--
作者：
Chiu, CC;Yeh, SJ
应用预过滤平均动脉血压（MABP）和平均脑血流速度（MCBFV）的时域互相关分析来评估脑自动调节（CA）。使用 Finapres 装置和经颅多普勒仪，从 13 名年轻正常志愿者仰卧位获得大约 5 分钟的自发动脉血压和脑血流速度的逐次心跳时间序列。使用 64 拍宽的移动窗口估计互相关函数 (CCF)。获得每个受试者和整个人群的平均 CCF 模式。在应用 CCF 之前，MABP 和 MCBFV 信号在极低频范围（VLF，0.015-0.07 Hz）、低频范围（LF，0.07-0.15 Hz）和高频范围（HF，0.15-0.40 Hz）进行带通滤波，目的是研究不同带宽对所得平均 CCF 的影响。结果显示，MABP-MCBFV CCF 峰值的相应时滞在 LF 和 BY 频率范围之间显着增加（LF：-1.20 +/- 0.91 s，HF：-0.07 +/- 0.42 s，p < 0.001；配对符号检验）。 MABP 和 MCBFV 之间的 CCF 峰值左移（负滞后）是相位超前特性的结果。 CCF 峰值的时间滞后增加表明存在自动调节紊乱。预过滤自发 MABP 和 MCBFV 的 CCF 可能是估计 CA 动态响应的有用工具。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
Time domain cross-correlation analysis of pre-filtered mean arterial blood pressure (MABP) and mean cerebral blood flow velocity (MCBFV) was applied to assess the cerebral autoregulation (CA). Beat-to-beat time series of spontaneous arterial blood pressure and cerebral blood flow velocity were obtained from 13 young normal volunteers with the Finapres device and the transcranial Doppler for periods of approximately 5 min in the supine position. Cross-correlation functions (CCFs) were estimated using a 64 beat wide moving window. Mean CCF patterns were obtained for each subject and for the entire population. The MABP and MCBFV signals were bandpass filtered in the very low-frequency range (VLF, 0.015-0.07 Hz), low-frequency range (LF, 0.07-0.15 Hz) and high-frequency range (HF, 0.15-0.40 Hz) before applying CCF for the purpose of studying the effect of different bandwidths on the resulting mean CCFs. Results revealed that the corresponding time lags of the peak values of the MABP-MCBFV CCFs increased significantly between the LF and BY frequency ranges (LF: -1.20 +/- 0.91 s, HF: -0.07 +/- 0.42 s, p < 0.001; paired sign test). The left-shift (negative lag) of the CCF peak between MABP and MCBFV is a result of the phase-lead property. The increasing time lag of the CCF peak indicated evidence of the autoregulatory disturbance. The CCF of pre-filtered spontaneous MABP and MCBFV could be a useful tool to estimate the CA dynamic response. (C) 2001 Elsevier Science Ltd. All rights reserved.