Targeting PFKFB3 in the Endothelium for Cancer Therapy.
Targeting PFKFB3 in the Endothelium for Cancer Therapy.
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DOI：
10.1016/j.molmed.2017.01.008
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发表时间：
2017-03
影响因子：
13.6
通讯作者：
Qi Yang;P. Hou
中科院分区：
文献类型：
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作者：
Qi Yang;P. Hou
Cantelmo等人在最近发表在《Cancer Cell》上的一篇文章中表明，通过靶向6-磷酸果糖2-激酶/果糖-2,6-二磷酸酶3 (PFKFB3) 来抑制内皮糖酵解，可通过使肿瘤血管正常化而显着损害肿瘤转移。此外，作为一种有前途的治疗策略，通过PFKFB3阻断实现肿瘤血管正常化也改善了化疗的递送和疗效。
In a recent article published inCancer Cell, Cantelmoet al.showed that inhibition of endothelium glycolysis by targeting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) significantly impaired tumor metastasis by normalizing tumor vessels. In addition, as a promising therapeutic strategy, tumor vessel normalization by PFKFB3 blockade also improved the delivery and efficacy of chemotherapy.