Estimation of bone permeability considering the morphology of lacuno-canalicular porosity
Estimation of bone permeability considering the morphology of lacuno-canalicular porosity
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DOI：
10.1016/j.jmbbm.2009.10.005
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发表时间：
2010-04-01
影响因子：
3.9
通讯作者：
Hojo, Masaki
中科院分区：
文献类型：
--
作者：
Kameo, Yoshitaka;Adachi, Taiji;Hojo, Masaki
载荷诱导的腔隙-小管孔隙间质液流动被认为在调节适应性骨重建的细胞活动中起重要作用。为了研究基于孔隙弹性的间隙流体行为，重要的是确定各向异性渗透率张量，其反映了作为流体通道的空隙-小管孔隙的形态特征。在这项研究中，我们提出了一种估计方法的小梁渗透性描述的体积取向（VO）的织物张量，它代表小管方向，和渗透性张量之间的分析关系。该关系表明，小梁渗透性张量与间质液体积分数和小管VO结构张量的乘积成正比。我们将所提出的方法应用于小梁横截面的二维荧光图像，以量化小管各向异性和小梁渗透性张量。结果表明，毛细血管小管主要沿骨小梁的径向排列，其通透性与小管的形态密切相关。(C)2009爱思唯尔有限公司保留所有权利。
Load-induced interstitial fluid flow in lacuno-canalicular porosity is believed to play an important role in cellular activities regulating adaptive bone remodeling. To investigate interstitial fluid behavior based on poroelasticity, it is important to determine the anisotropic permeability tensor reflecting the morphological features of the lacuno-canalicular porosity as fluid channels. In this study, we presented an estimation method of trabecular permeability by describing the analytical relationship between the volume orientation (VO) fabric tensor, which represents the canalicular orientation, and the permeability tensor. The relationship showed that the trabecular permeability tensor is proportional to the product of the volume fraction of the interstitial fluid and the VO fabric tensor of the canaliculi. We applied the proposed method to a two-dimensional fluorescent image of a trabecular cross section to quantify the canalicular anisotropy and the trabecular permeability tensor. The results indicated that the canaliculi are predominantly oriented in the radial direction of the trabecula, and the permeability depends strongly on the canalicular morphology. (C) 2009 Elsevier Ltd. All rights reserved.