Higher circulating mPNA levels of placental specific genes in a patient with placenta accreta
Higher circulating mPNA levels of placental specific genes in a patient with placenta accreta
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植入性胎盘患者胎盘特异性基因的循环 mPNA 水平较高
DOI：
10.1002/pd.2761
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Rizzo N
中科院分区：
文献类型：
--
作者：
Simonazzi G;Farina A;Curti A;Pilu G;Santini D;Zucchini C;Sekizawa A;Rizzo N
在妊娠32周时，收集外周母血样品用于测量Ki-67、KiSS-1转移抑制因子（KISS 1）、PLAC1、PlGF、VEGF和Flt-1基因的mRNA。mRNA样品的量以每毫升的拷贝数表示，并且还在32名妊娠31至33周且具有正常胎盘的孕妇（对照）中进行测量。所有纳入研究的病例均在孕早期进行超声检查。将拷贝数转换为未受影响妊娠的中位数（MoM）的倍数。正态分布采用Kolmogorov-Smirnov检验。由于我们只有一例胎盘植入的病例，所以我们只通过肉眼观察来检查和比较数据，我们的结果与KISS 1、PLAC1和VEGF基因可能参与胎盘植入的发展相一致。这些结果可以允许在有分子遗传学实验室的中心进行更深入的妊娠期随访
At 32 weeks of gestation, a peripheral maternal blood sample was collected for measurement of mRNAs for Ki-67, KiSS-1 metastasis-suppressor (KISS1), PLAC1, PlGF, VEGF and Flt-1 genes. Amounts of mRNA samples were expressed in terms of copies per millilitre and were also measured in 32 pregnant women at 31 to 33 gestational weeks with normal placentation (controls). All the cases included in the study were dated by ultrasound in the first trimester. Copies were converted into multiples of the median (MoM) of unaffected pregnancies. Normal distribution was tested by Kolmogorov–Smirnov test. As we had only one case of placenta accreta data were examined and compared only by visual inspection.Our results are consistent with a possible involvement of KISS1, PLAC1 and VEGF genes in placenta accreta development. These results could allow a more in depth follow-up during the pregnancy in centers where molecular genetics laboratories are available