The virulence for gnotobiotic pigs of live attenuated vaccine strains of Salmonella enterica serovars Typhimurium and Enteritidis
The virulence for gnotobiotic pigs of live attenuated vaccine strains of Salmonella enterica serovars Typhimurium and Enteritidis
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DOI：
10.1016/s0264-410x(01)00065-2
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发表时间：
2001-05-14
期刊：
影响因子：
5.5
通讯作者：
Lovell, MA
中科院分区：
文献类型：
--
作者：
Barrow, PA;Page, K;Lovell, MA
将无菌猪口服接种野生型或特定的aroA或W cr clp疫苗株，这些疫苗株分别来自肠道沙门氏菌血清型鼠伤寒沙门氏菌和肠炎沙门氏菌。亲本菌株具有致病性，可导致严重腹泻、脱水和全身性疾病。cya crp突变株也具有高度致病性，而aroA菌株则是减毒的。（C）2001爱思唯尔科学有限公司。保留所有权利。
Gnotobiotic pigs were inoculated orally with wild-type or defined aroA or. W cr clp vaccine strains of Salmonella enterica serovars Typhimurium and S. Enteritidis. The parental strains were virulent, inducing severe diarrhoea, dehydration and systemic disease. The cya crp mutant was also highly virulent whereas the aroA strains were attenuated. (C) 2001 Elsevier Science Ltd. All rights reserved.