Comparison of wire and disc electrodes to electrically activate the inspiratory muscles in dogs.
Comparison of wire and disc electrodes to electrically activate the inspiratory muscles in dogs.
复制标题
丝电极和盘电极电刺激犬吸气肌的比较。
DOI：
10.1016/j.jneumeth.2021.109176
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发表时间：
2021-06-01
影响因子：
3
通讯作者：
DiMarco AF
中科院分区：
文献类型：
--
作者：
Kowalski KE;DiMarco AF
比较金属丝电极与圆盘电极通过高频脊髓刺激激活吸气肌的有效性。动物实验。研究实验室。犬（n=5）在单独试验中，通过圆盘（DE）和两个平行线电极（WE）在T2-T3脊髓区域的腹侧硬膜外腔上施加脊髓刺激（SCS）。比较DE和WE刺激后的气道压力（P）和吸气量（V）生成。鉴于我们之前使用（DE）的成功，使用该电极的结局变量被用作我们进行所有比较的金标准。使用单极刺激（MS）的WE的两种配置产生的P和V与使用DE的MS产生的P和V相似。例如，具有并联WE连接在一起以用作公共阴极（Y连接）和2通道系统（具有远程接地的单独阴极）的MS导致P分别为DE（两者均为NS）所实现的P的91±6和92± 4%。使用Y型连接和双通道系统的平行WE的双极刺激产生的P分别为DE获得的P的96±4和94± 4%（两者均为NS）。这些结果表明，WE的特定配置，可以通过微创技术放置，提供了相当的吸气肌相比，DE激活，并可能是一个有用的技术，以恢复脊髓损伤的人的呼吸支持。
To compare the effectiveness of wire versus disc electrodes to activate the inspiratory muscles via high frequency spinal cord stimulation. Animal study. Research laboratory. Dogs (n=5) In separate trials, spinal cord stimulation (SCS) was applied via disc (DE) and two parallel wire electrodes (WE) on the ventral epidural space at the T2-T3 spinal region. Airway pressure (P) and inspired volume (V) generation following stimulation with DE and WE were compared. Given our previous success with (DE), outcome variables with this electrode were used as our gold standard to which all comparisons were made. Two configurations of WE using monopolar stimulation (MS) resulted in P and V that were similar to those generated with MS with DE. For example, MS with parallel WE connected together to function as a common cathode (Y-connection) and a 2-channel system (separate cathodes with a remote ground), resulted in P that were 91±6 and 92±4%, respectively, of those achieved with DE (NS for both). Bipolar stimulation with parallel WE using a Y-connection and with a 2-channel system, resulted in P that were 96±4 and 94±4%, of the P achieved with DE (NS for both). These results suggest that specific configurations of WE, which can be placed via minimally invasive techniques, provide comparable activation of the inspiratory muscles compared to DE and may be a useful technique to restore ventilatory support in persons with spinal cord injury.
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DOI：
10.1097/phm.0000000000001018
发表时间：
2019-01-01
影响因子：
3
作者：
DiMarco, Anthony F.;Geertman, Robert T.;Kowalski, Krzysztof E.
通讯作者：
Kowalski, Krzysztof E.
影响因子：
3.8
作者：
GRANDJEAN, PA;MORTIMER, JT
通讯作者：
MORTIMER, JT
影响因子：
1.7
作者：
Kowalski, Krysztof E.;DiMarco, Anthony F.
通讯作者：
DiMarco, Anthony F.
影响因子：
9.6
作者：
DEVIVO, MJ;IVIE, CS
通讯作者：
IVIE, CS
影响因子：
3.3
作者：
DiMarco, Anthony F.;Kowalski, Krzysztof E.
通讯作者：
Kowalski, Krzysztof E.