THE EPIDERMIS - RISING TO THE SURFACE
THE EPIDERMIS - RISING TO THE SURFACE
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DOI：
10.1016/0959-437x(94)90140-x
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发表时间：
1994-10-01
影响因子：
4
通讯作者：
BYRNE, C
中科院分区：
文献类型：
--
作者：
FUCHS, E;BYRNE, C
在皮肤表面，表皮具有重要的保护功能，这一功能通过构建广泛的角蛋白丝细胞骨架结构（从核膜到半桥粒和桥粒）来体现。最近对表皮蛋白及其相互作用的研究为人类皮肤疾病提供了见解，包括角蛋白、层粘连蛋白和胶原蛋白的遗传性疾病。对表皮基因调控机制的探索强调了转录因子 AP-1 和 AP-2、视黄酸受体和 POU 蛋白的重要性。对 TGF-α 和 TGF-β 基因的转基因和基因消融实验为表皮如何维持生长和分化细胞的平衡提供了线索。
At the skin surface, the epidermis serves an important protective function which it manifests by building an extensive cytoskeletal architecture of keratin filaments, spanning from the nuclear envelope to hemidesmosomes and desmosomes. Recent studies on epidermal proteins and their interactions have provided insights into human skin diseases, including genetic disorders of keratins, laminins and collagen. Explorations into the regulatory mechanisms underlying epidermal genes have underscored the importance of transcription factors AP-1 and AP-2, retinoic acid receptors, and POU proteins. Transgenic and gene ablation experiments on TGF-alpha and TGF-beta genes have yielded clues as to how the epidermis maintains a balance of growing and differentiating cells.