Ubiquitin and ubiquitin-like modifications of the p53 family.
Ubiquitin and ubiquitin-like modifications of the p53 family.
复制标题
p53 家族的泛素和泛素样修饰。
作者：
I. Watson;M. Irwin
通过泛素-蛋白酶体途径对p53的调节已经被大量研究。研究还表明，泛素样蛋白SUMO-1和NEDD 8修饰p53。类似地，p63和p73受到泛素和泛素样修饰的调节，并且这些通路在p53家族调节中的扰动与肿瘤发生和发育异常有关。在这里，我们提供了一个概述目前的理解，通过泛素，SUMO-1和NEDD 8共价修饰的p53家族的调节。
Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developmental abnormalities. Here, we provide an overview of the current understanding of the regulation of the p53 family by covalent modification by ubiquitin, SUMO-1, and NEDD8.
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影响因子：
5.3
作者：
T. Nakagawa;M. Takahashi;T. Ozaki;Ken-ichi Watanabe Ki;S. Todo;H. Mizuguchi;T. Hayakawa;A. Nakagawara-A.
通讯作者：
T. Nakagawa;M. Takahashi;T. Ozaki;Ken-ichi Watanabe Ki;S. Todo;H. Mizuguchi;T. Hayakawa;A. Nakagawara-A.
影响因子：
4.3
作者：
A. Fomenkov;R. Zangen;Yiping Huang;M. Osada;Zhongmin Guo;Tanya Fomenkov;B. Trink;D. Sidransky;E. Ratovitski
通讯作者：
A. Fomenkov;R. Zangen;Yiping Huang;M. Osada;Zhongmin Guo;Tanya Fomenkov;B. Trink;D. Sidransky;E. Ratovitski
影响因子：
4.3
作者：
M. Westfall;Amanda S. Joyner;C. Barbieri;M. Livingstone;J. Pietenpol
通讯作者：
M. Westfall;Amanda S. Joyner;C. Barbieri;M. Livingstone;J. Pietenpol
影响因子：
50.3
作者：
Rocco, JW;Leong, CO;Ellisen, LW
通讯作者：
Ellisen, LW
DOI：
10.1073/pnas.0602477103
发表时间：
2006-05-30
影响因子：
11.1
作者：
Keyes, William M.;Vogel, Hannes;Mills, Alea A.
通讯作者：
Mills, Alea A.