CSF monoamine metabolites and MRI brain volumes in alcohol dependence
CSF monoamine metabolites and MRI brain volumes in alcohol dependence
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DOI：
10.1016/s0925-4927(02)00084-7
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发表时间：
2003-01-20
影响因子：
2.3
通讯作者：
Hommer, DW
中科院分区：
文献类型：
--
作者：
Agartz, I;Shoaf, S;Hommer, DW
精神分裂症患者脑脊液中单胺类代谢产物(MAM)浓度与脑结构之间的相关性已在精神分裂症患者中得到了描述，但在酒精中毒患者中未见报道。为探讨酒依赖患者单胺能传递与脑结构的关系，测定了54例酒依赖患者和20例健康人腰脑脊液中多巴胺(高香草酸)、去甲肾上腺素(MHPG)和5-羟基吲哚乙酸(5-HIAA)的代谢产物。MRI测量大脑体积、总灰质和白质、总脑脊液和脑室脑脊液、左、右海马体和胼胝体面积。酗酒女性的MHPG与年龄呈正相关。在受试者类别中，MAM浓度与MRI体积无显著相关性。在不同诊断和性别、酒精中毒发病年龄或精神障碍共病的受试者中，MAM没有差异。脑脊液、大脑、白质和灰质组织体积在患者和健康受试者之间有所不同。最大的区别是酗酒女性的脑白质减少。在酗酒的女性和男性中，用脑脊液MAM HVA、MHPG和5-HIAA测量的单胺能神经传递与不同大脑结构的大小没有明显的相关性。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Correlations between cerebrospinal fluid (CSF) concentrations of monoamine metabolites (MAM) and brain structure have been described in schizophrenia, but not in alcoholism. To investigate the relationship between monoaminergic transmission and brain structure in alcoholism, the metabolites of dopamine (homovanillic acid, HVA), norepineptirenine (3-methoxy-4-hydroxyphenylethyleneglycol, MHPG) and serotonin (5-hydroxyindoleacetic acid, 5-HIAA) were measured in lumbar CSF in 54 alcohol-dependent patients and 20 healthy subjects. The volumes of the cerebrum, total grey and white matter, total and ventricular CSF, left and right hippocampus, and corpus callosum area were measured with MRI. MHPG and age were positively correlated in alcoholic women. The MAM concentrations were not significantly correlated with the MRI volumes in the subject categories. There were no differences in MAM across subjects defined by diagnosis and gender, age of onset of alcoholism or comorbidity of psychiatric disorders. Total CSF, cerebrum, and white and grey matter tissue volumes differed between patients and healthy subjects. The greatest difference was the white matter reduction in alcoholic women. In alcoholic women and men, monoaminergic neurotransmission measured by the CSF MAM HVA, MHPG, and 5-HIAA is not significantly correlated with the size of different brain structures. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.