Mild conditions for copper-catalyzed coupling reaction of phenols and aryl iodides and bromides
Mild conditions for copper-catalyzed coupling reaction of phenols and aryl iodides and bromides
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DOI：
10.1002/adsc.200505385
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发表时间：
2006-03-01
影响因子：
5.4
通讯作者：
Taillefer, M
中科院分区：
文献类型：
--
作者：
Ouali, A;Spindler, JF;Taillefer, M
酚和芳基溴的偶联可以通过催化量的碘化铜和廉价的配体1（结构在表1中给出）有效地进行。该反应适用于广泛的底物，并在60-80 ℃下进行，这是迄今为止报道的Ullmann型二芳基醚合成的最低温度。此外，使用芳基溴和廉价的K3 PO 4作为碱使得该方法对于工业规模的应用具有吸引力。
Coupling of phenols and aryl bromides can be efficiently performed by means of catalytic amounts of copper iodide and the inexpensive ligand 1 (structure given in Table 1). The reaction is applicable to a wide range of substrates and proceeds at 60-80 degrees C, the lowest temperatures reported to date for an Ullmann-type synthesis of diaryl ethers. Moreover, the use of aryl bromides and inexpensive K3PO4 as base make this method attractive for applications on an industrial scale.