Nodal Morphogens
Nodal Morphogens
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DOI：
10.1101/cshperspect.a003459
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发表时间：
2009-11-01
影响因子：
7.2
通讯作者：
Schier, Alexander F.
中科院分区：
文献类型：
--
作者：
Schier, Alexander F.
节点信号属于 TGF-β 超家族，对于中胚层和内胚层的诱导以及左右轴的确定至关重要。节点信号可以充当形态发生素——它们具有浓度依赖性效应，并且可以在远离其产生源的地方起作用。 Nodal 及其反馈抑制剂 Lefty 形成激活剂/抑制剂对，其行为类似于假设的组织模式反应扩散模型。节点形态发生素活性还受到 microRNA、转化酶、TGF-β 信号、共受体和运输因子的调节。本文描述了节点形态发生素如何形成胚胎场模式，并讨论了节点形态发生素信号传导是如何调节的。
Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, co-receptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated.