Isolation, structure determination, and synthesis of neodysiherbaine A, a new excitatory amino acid from a marine sponge
Isolation, structure determination, and synthesis of neodysiherbaine A, a new excitatory amino acid from a marine sponge
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DOI：
10.1021/ol015798l
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发表时间：
2001-05-17
期刊：
影响因子：
5.2
通讯作者：
Kamiya, H
中科院分区：
文献类型：
--
作者：
Sakai, R;Koike, T;Kamiya, H
从海绵Dyside a herbacea的水提物中分离得到一种新的兴奋性氨基酸--新羟基丁酸A(2)。该化合物的结构由波谱方法推导，并通过全合成明确确定。目前的合成，包括作为关键步骤的6/5-双环核心与氨基酸残基的交叉偶联，在构建其结构类似物方面是有用的。
A new excitatory amino acid, neodysiherbaine A (2), was isolated as a minor constituent of the aqueous extract from the marine sponge Dysidea herbacea. The structure was deduced by spectroscopic methods and established unambiguously by the total synthesis. The present synthesis, including as a key step cross coupling of the 6/5-bicyclic core with an amino acid residue, is useful in constructing its structural analogues.