Hepatic CYP3A4,SULT2A1,and UGT1A1 synergistically mediate metabolic detoxification of genipin
Hepatic CYP3A4,SULT2A1,and UGT1A1 synergistically mediate metabolic detoxification of genipin
复制标题
DOI：
10.5246/jcps.2022.08.051
复制
发表时间：
2022
影响因子：
--
通讯作者：
Wei Yuhui
中科院分区：
文献类型：
--
作者：
Zhang Fan;Wang Xiaohui;Saad Abdulaziz Ahmed A;Xi Lili;Ma Xiaohua;Shi Axi;Wei Yuhui
In the present study,we aimed to ascertain the metabolic detoxification routes of genipin via CYP3A4,SULT2A1,and UGT1A1 in HepaRG cells.It was found that the hepatic CYP3A4,SULT2A1,and UGT1A1 synergistically mediated the metabolic detoxification of genipin,and the CYP3A4 was the limited enzyme.In detail,the pivotal detoxification pathway was CYP3A4-SULT2A1/UGT1A1,indicating that SULT2A1 and UGT1A1 further catalyzed the phase II detoxification metabolism followed by the genipin metabolization by CYP3A4 to the phase I metabolites with alleviated toxicity.Our findings provided valuable cues for future studies on the detoxification of genipin,even the compatibility detoxification of Zhi-zi.Moreover,these data facilitated the development and rational administration of genipin and Zhi-zi.
