Hepatitis B virus DNA during pregnancy and post partum:: Aspects on vertical transmission
Hepatitis B virus DNA during pregnancy and post partum:: Aspects on vertical transmission
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DOI：
10.1080/00365540310016547
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发表时间：
2003-12-01
影响因子：
--
通讯作者：
Lindh, M
中科院分区：
文献类型：
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作者：
Söderström, A;Norkrans, G;Lindh, M
关于妊娠如何影响慢性B型肝炎病毒感染妇女的病毒血症水平知之甚少。在这项研究中，我们首先回顾性分析了55例HBeAg阳性妇女（其中9例HBeAg阳性）妊娠期间和妊娠后HBV DNA水平的变化。其次，比较3例HBeAg阳性母亲的婴儿成为慢性HBV携带者的HBV DNA水平，并与18例未感染HBV的婴儿的母亲的HBV DNA水平进行比较。我们发现HBeAg阳性者HBV DNA的范围为10（8.1）至10（9.5）拷贝/mL，妊娠期间为无法检测到（1 log）。HBeAg阳性和阴性妇女产后ALT均升高。3例HBeAg阳性母亲的新生儿垂直感染时HBVDNA为10（9.4）~ 10（10.4）拷贝/mL，而18例新生儿垂直感染时HBVDNA < 100-10（10.4）拷贝/mL。虽然大多数HBeAg阴性的妇女在怀孕期间HBV DNA水平较低且相对稳定，但在一些HBeAg阴性的母亲中病毒血症也相对较高，并且病毒血症和ALT在怀孕后期或分娩后不久显著升高。垂直传播仅见于HBeAg阳性且病毒血症水平极高的母亲。孕妇血清HBV DNA检测对调整新生儿免疫预防的价值有待进一步研究。
Little is known about how pregnancy influences viremia levels in women with chronic hepatitis B virus infection. In this study, we first retrospectively analysed changes in HBV DNA levels during and after 55 pregnancies in HBsAg-positive women, of whom 9 were HBeAg-positive. Secondly, HBV DNA levels in 3 HBeAg-positive mothers whose babies became chronic HBV carriers, were compared with levels in 18 mothers whose babies were not infected by HBV. We found that HBV DNA ranged from 10(8.1) to 10(9.5) copies/mL in HBeAg-positive, and from undetectable ( 1 log during pregnancy. Post partum ALT increased in both HBeAg-positive and negative women. HBV DNA was 10(9.4)-10(10.4) copies/mL in 3 HBeAg-positive mothers whose babies were, as compared to < 100-10(10.4) copies/mL in 18 whose babies were not, vertically infected. Although the majority of HBeAg-negative women had low and relatively stable HBV DNA during pregnancy, viremia was also relatively high in some HBeAg-negative mothers, and both viremia and ALT increased significantly late in pregnancy or shortly after delivery. Vertical transmission was only seen in HBeAg-positive mothers with very high levels of viremia. The value of measuring HBV DNA in the pregnant woman to modify immunoprophylaxis to her infant needs further study.