Cytokines and the microcirculation in ischemia and reperfusion
Cytokines and the microcirculation in ischemia and reperfusion
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DOI：
10.1006/jmcc.1998.0829
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发表时间：
1998-12-01
影响因子：
5
通讯作者：
Entman, ML
中科院分区：
文献类型：
--
作者：
Frangogiannis, NG;Youker, KA;Entman, ML
梗死心肌再灌注后的强烈炎症反应被认为是损伤扩展的一个因素。然而，这种炎症反应对组织修复也至关重要。介导这些功能的细胞应答通过细胞因子的顺序诱导和/或释放来协调，导致密切调节的细胞因子级联。本文综述了这些细胞因子级联反应的研究，它们的细胞起源，以及控制细胞反应的因素。检查的因素包括白细胞的趋化性，白细胞的表型转变，粘附分子诱导和细胞因子在组织修复和瘢痕形成中的作用。(C)北京：科学出版社.
The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induction and/or release of cytokines resulting in a closely regulated cytokine cascade. This paper reviews research on these cytokine cascades, their cellular origin, and factors which control the cellular response to their presence. Factors examined include leukotaxis, phenotypic transition of leukocytes, adhesion molecule induction and the role of cytokines in tissue repair and scar formation. (C) 1998 Academic Press.