Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor
Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor
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DOI：
10.1111/j.1440-1827.2011.02761.x
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发表时间：
2012-02-01
影响因子：
2.2
通讯作者：
Koo, Ja Seung
中科院分区：
文献类型：
--
作者：
Choi, Junjeong;Koo, Ja Seung
我们对 129 例经手术证实的叶状肿瘤 (PT) 患者的空心针活检 (CNB) 和手术切除标本的组织病理学特征进行了比较分析。评估了基质特征，包括细胞结构、异型性、有丝分裂、过度生长、组织碎片和肿瘤边缘。 90 (69.8%)/30 (23.3%)/9 (7.0%) 例患者诊断为良性/交界性/恶性叶状肿瘤 (PT)。 90例良性PT中，CNB一致诊断67例（74.4%）。对于交界性和恶性 PT，八分之三 (26.6%) 和九分之四 (44.4%) 病例在 CNB 中得到一致诊断。所有 50 例诊断不一致的病例在匹配的 CNB 中均被低估，尤其是在基质细胞结构和有丝分裂方面。 PT不一致的病例肿瘤尺寸较大（P=0.013）。 CNB与手术切除的诊断一致率约为60%，因此，基于CNB组织学结果的PT分级具有局限性。这种不一致来自于 PT 的异质基质特性。
We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23.3%)/9 (7.0%) patients. Among the 90 cases of benign PTs, 67 cases (74.4%) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6%) and four out of nine (44.4%) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discordant cases of PT (P= 0.013). The concordant rate of diagnosis between CNB and surgical excision was about 60% and accordingly, grading of PT based on the histological findings in CNBs has limitation. The discordance comes from heterogeneous stromal properties of PTs.