Arf family GTP loading is activated by, and generates, positive membrane curvature.
Arf family GTP loading is activated by, and generates, positive membrane curvature.
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DOI：
10.1042/bj20081237
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发表时间：
2008-09-01
期刊：
影响因子：
--
通讯作者：
McMahon HT
中科院分区：
文献类型：
--
作者：
Lundmark R;Doherty GJ;Vallis Y;Peter BJ;McMahon HT
属于Arf（ADP-核糖基化因子）家族的小G蛋白通过GTP依赖性募集效应分子作为许多细胞过程的调节蛋白。在本研究中，我们表明，在这个家庭中的蛋白质调节，并调节，膜曲率。Arf 1和Arf 6被证明以膜曲率依赖性的方式加载GTP，并通过插入两亲性螺旋来稳定或进一步促进膜曲率的变化。
Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curvature. Arf1 and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix.