Both α- and β-carotene, but not Tocopherols and vitamin C, are inversely related to 15-year cardiovascular mortality in dutch elderly men
Both α- and β-carotene, but not Tocopherols and vitamin C, are inversely related to 15-year cardiovascular mortality in dutch elderly men
复制标题
DOI：
10.1093/jn/138.2.344
复制
发表时间：
2008-02-01
影响因子：
4.2
通讯作者：
Kromhout, Daan
中科院分区：
文献类型：
--
作者：
Buijsse, Brian;Feskens, Edith J. M.;Kromhout, Daan
β-胡萝卜素、α-生育酚和维生素C在预防心血管疾病(CVD)中的作用存在争议。除了β-胡萝卜素之外，关于γ-生育酚和类胡萝卜素的前瞻性研究很少。我们在参与Zutphen老年研究的老年男性中评估了不同类胡萝卜素、α-和γ-生育酚的摄入量以及维生素C与15岁心血管疾病死亡率之间的关系。有关饮食和潜在混杂因素的信息收集于1985年、1990年和1995年。1985年，559名无慢性病的男性(平均年龄72岁)被纳入本次分析。经过15年的随访，共5744人年，197名男性死于心血管疾病。在调整了年龄、吸烟和其他潜在的生活方式和饮食混杂因素后，增加1-SD摄入量导致心血管疾病死亡的相对风险(RR)(95%CI)对于a-胡萝卜素为0.81(0.660-99)，对于β-胡萝卜素为0.80(0.66-0.97)。胡萝卜是α-胡萝卜素和β-胡萝卜素的主要来源，胡萝卜的摄入量与较低的心血管疾病死亡风险有关(调整后的RR为0.83；95%CI=0.68-1.00)。摄入非α-和β-胡萝卜素的类胡萝卜素与心血管疾病死亡率无关，维生素C和α-和伽马生育酚也不相关。总而言之，老年男性饮食中a-胡萝卜素和6-胡萝卜素的摄入量与心血管疾病死亡率呈负相关。这项研究没有表明其他类胡萝卜素、生育酚或维生素C在降低心血管疾病死亡风险方面起着重要作用。
The role of beta-carotene, alpha-tocopherol, and vitamin C in the prevention of cardiovascular diseases (CVD) is controversial. Prospective studies on gamma-tocopherol and carotenoids other than beta-carotene are sparse. We assessed relations between the intake of different carotenoids, alpha- and gamma-tocopherol, and vitamin C with 15-y CVD mortality in elderly men who participated in the Zutphen Elderly Study. Information on diet and potential confounding factors was collected in 1985, 1990, and 1995. In 1985, 559 men (mean age -72 y) free of chronic diseases were included in the current analysis. After 15 y of follow-up, comprising 5744 person-years, 197 men had died from CVD. After adjustment for age, smoking, and other potential lifestyle and dietary confounders, relative risks (RR) (95% Cl) of CVD death for a 1-SD increase in intake were 0.81 (0.660-99) for a-carotene and 0.80 (0.66-0.97) for beta-carotene. Carrots were the primary source of alpha- and beta-carotene and their consumption was related to a lower risk of death from CVD (adjusted RR, 0.83; 95% Cl = 0.68-1.00). Intakes of carotenoids other than alpha-and beta-carotene were not associated with CVD mortality, nor were vitamin C and alpha-and gamma tocopherol. In conclusion, dietary intakes of a-carotene and 6-carotene are inversely associated with CVD mortality in elderly men. This study does not indicate an important role for other carotenoids, tocopherols, or vitamin C in lowering the risk of CVD death.